1. NF-κB
    Stem Cell/Wnt
  2. NF-κB
    Wnt
  3. Specnuezhenide

Specnuezhenide (Synonyms: (8E)-Nuezhenide)

Cat. No.: HY-N0665
Handling Instructions

Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA).

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Specnuezhenide Chemical Structure

Specnuezhenide Chemical Structure

CAS No. : 39011-92-2

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Description

Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1].

In Vitro

Specnuezhenide (0.2-5.0 μg/mL) significantly decreases the mRNA expression of VEGFA induced by CoCl2 as a dose-dependent manner in ARPE-19 cells[2].

Molecular Weight

686.66

Formula

C₃₁H₄₂O₁₇

CAS No.

39011-92-2

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Keywords:

Specnuezhenide(8E)-NuezhenideNF-κBWntNuclear factor-κBNuclear factor-kappaBosteoarthritisOAdiabetic retinopathyanti-angiogenicInhibitorinhibitorinhibit

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