2. Immunology/Inflammation
  3. COX
  4. Tinoridine

Tinoridine  (Synonyms: Y-3642)

Cat. No.: HY-W032848 Purity: 99.00%
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Tinoridine (Y-3642) is an orally active non-steroidal anti-inflammatory agent with potent antiperoxidative ability and radical scavenger activity. Tinoridine acts function by inhibiting COX enzyme, involves in hepatotoxicity inhibition. .

For research use only. We do not sell to patients.

Tinoridine Chemical Structure

Tinoridine Chemical Structure

CAS No. : 24237-54-5

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Tinoridine Related Antibodies

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Description

Tinoridine (Y-3642) is an orally active non-steroidal anti-inflammatory agent with potent antiperoxidative ability and radical scavenger activity. Tinoridine acts function by inhibiting COX enzyme, involves in hepatotoxicity inhibition. [1][2][3].

In Vitro

Tinoridine (10-100 μM) exerts effect on stability of rat liver and kidney lysosomes, and liver parenchymal cells[3].
Tinoridine (1, 10, and 100 μM; 30 min) inhibits spontaneous release of acid phosphatase from liver lymomoses in vitro[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tinoridine Related Antibodies
In Vivo

Tinoridine (100 mg/kg; p.o.; single dose) inhibits CCl4 hepatotoxicity in rats, with a strong control of the CCl4-induced enzyme activities[2].
Tinoridine (100 mg/kg; i.p.; single dose) protects the stability of rat liver and kidney lysosomes in vivo[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (180-220 g)[2]
Dosage: 100 mg/kg
Administration: Oral gavage; single dose; 1 hour before CCl4 (i.p.; 0.25 mL/kg) treatment
Result: Inhibited the CCl4-induced enzyme activities increase of serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and also rescued the liver microsomal cytochrome P-450 and glucose-6-phosphatase activities.
Clinical Trial
Molecular Weight

316.42

Formula

C17H20N2O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC(SC1=C2CCN(CC3=CC=CC=C3)C1)=C2C(OCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (395.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1604 mL 15.8018 mL 31.6036 mL
5 mM 0.6321 mL 3.1604 mL 6.3207 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1604 mL 15.8018 mL 31.6036 mL 79.0089 mL
5 mM 0.6321 mL 3.1604 mL 6.3207 mL 15.8018 mL
10 mM 0.3160 mL 1.5802 mL 3.1604 mL 7.9009 mL
15 mM 0.2107 mL 1.0535 mL 2.1069 mL 5.2673 mL
20 mM 0.1580 mL 0.7901 mL 1.5802 mL 3.9504 mL
25 mM 0.1264 mL 0.6321 mL 1.2641 mL 3.1604 mL
30 mM 0.1053 mL 0.5267 mL 1.0535 mL 2.6336 mL
40 mM 0.0790 mL 0.3950 mL 0.7901 mL 1.9752 mL
50 mM 0.0632 mL 0.3160 mL 0.6321 mL 1.5802 mL
60 mM 0.0527 mL 0.2634 mL 0.5267 mL 1.3168 mL
80 mM 0.0395 mL 0.1975 mL 0.3950 mL 0.9876 mL
100 mM 0.0316 mL 0.1580 mL 0.3160 mL 0.7901 mL
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Tinoridine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tinoridine24237-54-5Y-3642Y3642Y 3642COXCyclooxygenasespontaneous releaseliverkidneylysosomesparenchymal cellshepatotoxicityradical scavenger activitynonsteroidal anti-inflammatory agentNAIADInhibitorinhibitorinhibit

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