1. Neuronal Signaling
    Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
  2. Calcium Channel
    TRP Channel
    Endogenous Metabolite
  3. Cyclic ADP-​ribose

Cyclic ADP-​ribose (Synonyms: cADPR)

Cat. No.: HY-N7395
Handling Instructions

Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.

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Cyclic ADP-​ribose Chemical Structure

Cyclic ADP-​ribose Chemical Structure

CAS No. : 119340-53-3

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Description

Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1][2][3].

IC50 & Target

Calcium mobilization[1]
TRPM2 channels[3]
Endogenous metabolite[1]

In Vitro

cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates[1].
cADPR (100 µM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes[4].
cADPR (100 µM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

cADPR (100 µM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

541.30

Formula

C₁₅H₂₁N₅O₁₃P₂

CAS No.

119340-53-3

SMILES

O[[email protected]]([[email protected]@H]1O)[[email protected]](O[[email protected]]1([H])COP(O)(OP(O)(OC2)=O)=O)([H])N3C(N=CN([[email protected]]4([H])O[[email protected]@]2([H])[[email protected]@H](O)[[email protected]]4O)C5=N)=C5N=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Cyclic ADP-​ribosecADPRCalcium ChannelTRP ChannelEndogenous MetaboliteCa2+ channelsCa channelsTransient receptor potential channelsCD38calcium-mobilizingmessengerTRPM2RyanodineendoplasmicreticulumdifferentiationinflammatoryimmuneInhibitorinhibitorinhibit

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Cyclic ADP-​ribose
Cat. No.:
HY-N7395
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