1. MAPK/ERK Pathway
  2. p38 MAPK

Ferulic acid methyl ester (Synonyms: Methyl ferulate)

Cat. No.: HY-W018643 Purity: 99.18%
Handling Instructions

Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages.

For research use only. We do not sell to patients.

Ferulic acid methyl ester Chemical Structure

Ferulic acid methyl ester Chemical Structure

CAS No. : 2309-07-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties[1][2]. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders[1]. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages[2].

IC50 & Target[2]

p38

 

In Vitro

Ferulic acid methyl ester (25 µg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h[2].
Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 µg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 µg/mL, in primary bone marrow derived-macrophages (BMDMs)[2].
Ferulic acid methyl ester (25 µg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK[2].

Cell Viability Assay[2]

Cell Line: Primary bone marrow derived-macrophages (BMDMs)
Concentration: 25 µg/mL
Incubation Time: 6 h, 18 h, 48 h
Result: Showed no cytotoxic effects on BMDMs.

Western Blot Analysis[2]

Cell Line: RAW 246.7 cells
Concentration: 10 µg/mL and 25 µg/mL
Incubation Time: For 1 h before stimulation with LPS
Result: Significantly suppressed COX-2 expression at 25 µg/mL.
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8028 mL 24.0142 mL 48.0284 mL
5 mM 0.9606 mL 4.8028 mL 9.6057 mL
10 mM 0.4803 mL 2.4014 mL 4.8028 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

208.21

Formula

C₁₁H₁₂O₄

CAS No.

2309-07-1

SMILES

O=C(OC)/C=C/C1=CC=C(O)C(OC)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Ferulic acid methyl ester
Cat. No.:
HY-W018643
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Ferulic acid methyl ester

Cat. No.: HY-W018643