Stemonaceae

Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages.

Dihydropinosylvin is a stilbenoid that can be found in Stemona collinsae.

Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages.

Methyl 4-O-feruloylquinate (4-O-Feruloylquinic acid methyl ester) is a natural product. Methyl 4-O-feruloylquinate can be purified from Stemona Japonica by preparative high-performance liquid chromatography. Methyl 4-O-feruloylquinate has anti-H5N1 activity with a 3% protective rate at 5 μM in MDCK cells.

Protostemotinine is an alkaloid isolated from the roots and rhizomes of Stemona sessilifolia.

Croomine is a tuberostemospironine-type alkaloid. Croomine can be found in Stemona tuberosa, Croomia heterosepala, and Croomia japonica.

9α-epi-Tuberospironine A is a croomine-type stemona alkaloid found in the roots of Stemona tuberosa.

Oxystemoninine is a Stemona alkaloid of the stemonamide type, which can be isolated from the roots of Stemona tuberosa. Oxystemoninine exhibits ¹H- and ¹³C-NMR spectra similar to those of stemoninine (HY-134006).

Stenine (Compound 5) is an alkaloid found in the roots of Stemona sessilifolia.

10-Hydroxycroomine is a croomine-type alkaloid. 10-Hydroxycroomine can be isolated from the roots of Stemona tuberosa. 10-Hydroxycroomine produces a non-statistically significant reduction in Citric acid (HY-N1428)-induced coughing. 10-Hydroxycroomine can be used for the research of cough.

Sanggenol C is a natural flavonoid.

Tuberospironine A is a Stemona alkaloid compound; a series of Stemona alkaloids often exhibit pharmacological activities such as antitussive effects. Tuberospironine A can be naturally extracted from the dried roots of Stemona tuberosa Lour., which grows in Indonesia.

2-Oxostenine (Compound 7) is a stenine-type alkaloid found in the roots of Stemona tuberosa Lour. 2-Oxostenine can weakly inhibit Lipopolysaccharide (HY-D1056)-induced NO production. 2-Oxostenine can be used for the research of inflammation.

Tuberostemonine A is a natural product that can be found in Stemona tuberosa.

Bisdehydrotuberostemonine is an alkaloid found in the roots of Stemona sessilifolia.

Stemospironine is an alkaloid that can be extracted from plants of the genus Hyacinth. Stemospironine is a cough suppressant used to control coughing. Stemospironine can be used for research on inflammatory conditions.

Tuberostemonine D, an alkaloid obtained, can be obtained from the root of Stemona tuberosa.

Stemoninine is a lycoris alkaloid that can be used as an antitussive. Stemoninine has significant inhibitory activity against human acetylcholinesterase (AChE) (IC₅₀=5.52 μM).

Bisdehydroneotuberostemonine (Compound 4) is a kind of alkaloid. Bisdehydroneotuberostemonine is isolated from naturalStemona tuberosa.

Dehydro-δ-tocopherol (compound 1) is isolated from S. collinsae or S. tuberosa. Dehydro-δ-tocopherol shows antioxidant capacity, with the EC₅₀ of 25 μM.