2-Oxostenine
2-Oxostenine (Compound 7) is a stenine-type alkaloid found in the roots of Stemona tuberosa Lour. 2-Oxostenine can weakly inhibit Lipopolysaccharide (HY-D1056)-induced NO production. 2-Oxostenine can be used for the research of inflammation.
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- CAS No.: 18058-98-5
- Formule: C17H25NO3
- Masse moléculaire:291.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Description
Chemical Information
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CAS No. 18058-98-5
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Masse moléculaire 291.39
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Formule C17H25NO3
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SMILES
CC[C@@H]1[C@]2([H])[C@]3([H])[C@@](CC(N3CCCC2)=O)([H])[C@]4([H])[C@@]1([H])OC([C@H]4C)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Oxostenine Related Classifications
HY-N16537 Related Classifications
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