Florensocatib hydrate
Florensocatib hydrate (HSK31858 hydrate) is a potent reversible dipeptidyl peptidase 1 (DPP1) inhibitor with an IC50 of 1.6 nM against DPP1. Florensocatib hydrate inhibits DPP1 and thereby reduces DPP1-dependent maturation and activation of neutrophil serine proteases (NSPs). Florensocatib hydrate can be used in studies of bronchiectasis and neutrophilic inflammation.
For research use only. We do not sell to patients.
- CAS No.: 2971064-13-6
- Formula: C23H25FN4O5
- Molecular Weight:456.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DPP1 1.6 nM (IC50) |
Florensocatib hydrate (HSK31858 hydrate) exhibits high inhibitory potency against neutrophil serine protease activity in vitro[1].
Florensocatib hydrate (30 min) potently inhibits the activity of recombinant human DPP1 enzyme, with an IC50 value of 1.6 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2971064-13-6
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Molecular Weight 456.47
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Formula C23H25FN4O5
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SMILES
CN1C2=CC(C3=CC(F)=C(C=C3)C[C@@H](C#N)NC([C@@H]4CNCCCO4)=O)=CC=C2OC1=O.O
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Synonyms
HSK31858 hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Florensocatib hydrate Related Classifications
HY-160073A Related Classifications
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