2971064-13-6
2971064-13-6
Chemical Structure
Florensocatib hydrate
Synonym(s): HSK31858 hydrate
- CAS No.: 2971064-13-6
- Formula:C23H25FN4O5
- Molecular Weight:456.47
InChIKey: JMILEXZIBSOORU-PVMVIUQGSA-N
SMILES: CN1C2=CC(C3=CC(F)=C(C=C3)C[C@@H](C#N)NC([C@@H]4CNCCCO4)=O)=CC=C2OC1=O.O
Biological Activity: Florensocatib hydrate (HSK31858 hydrate) is a potent reversible dipeptidyl peptidase 1 (DPP1) inhibitor with an IC50 of 1.6 nM against DPP1. Florensocatib hydrate inhibits DPP1 and thereby reduces DPP1-dependent maturation and activation of neutrophil serine proteases (NSPs). Florensocatib hydrate can be used in studies of bronchiectasis and neutrophilic inflammation[1][2].
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Florensocatib hydrate | Florensocatib hydrate (HSK31858 hydrate) is a potent reversible dipeptidyl peptidase 1 (DPP1) inhibitor with an IC50 of 1.6 nM against DPP1. Florensocatib hydrate inhibits DPP1 and thereby reduces DPP1-dependent maturation and activation of neutrophil serine proteases (NSPs). Florensocatib hydrate can be used in studies of bronchiectasis and neutrophilic inflammation. | |||||||||||||||||||||
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References
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[1]. Zhong N, et al. Florensocatib in adults with bronchiectasis: The HOPE-BE trial protocol and baseline demographic characteristics. ERJ Open Research. 2026; in press.
- [2]. Fan J, et al. Dipeptidyl peptidase 1 inhibitor polymorph, preparation method and use therefor. WO2023160579A1. World Intellectual Property Organization. 2023-08-31.
