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Cat. No.: HY-160073

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Florensocatib

Name: Florensocatib
Brand: MedChemExpress
SKU: HY-160073
Price: 400.00 USD
Availability: PreOrder

(Synonyms: HSK31858)

Florensocatib (HSK31858) is a potent reversible dipeptidyl peptidase 1 (DPP1) inhibitor with an IC₅₀ of 1.6 nM against DPP1. By inhibiting the DPP1-dependent maturation of neutrophil serine proteases (NSPs), Florensocatib can be used in studies of bronchiectasis and neutrophilic inflammation.

For research use only. We do not sell to patients.

CAS No.: 2762114-61-2
Formula: C₂₃H₂₃FN₄O₄
Molecular Weight:438.45

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Florensocatib Chemical Structure

CAS No.: 2762114-61-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

DPP1

1.6 nM (IC₅₀)

All Dipeptidyl Peptidase Isoforms :

In Vitro

Florensocatib (HSK31858) (Comp I) exhibits high inhibitory potency against neutrophil serine protease activity in vitro^[1].
Florensocatib (30 min) potently inhibits the activity of recombinant human DPP1 enzyme, with an IC₅₀ value of 1.6 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	V_dss	AUC_0-t	F
Rat^[2]	1 mg/kg	i.v.	1.66 mL/min/kg	0.753 L/kg	9503 ng·h/mL	/
Rat^[2]	3 mg/kg	p.o.	/	/	31159 ng·h/mL	>100 %

Chemical Information

CAS No. 2762114-61-2
Appearance Solid
Molecular Weight 438.45
Formula C₂₃H₂₃FN₄O₄
Color White to off-white
SMILES

CN1C2=CC(C3=CC(F)=C(C=C3)C[C@@H](C#N)NC([C@@H]4CNCCCO4)=O)=CC=C2OC1=O
Synonyms

HSK31858
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhong N, et al. Florensocatib in adults with bronchiectasis: The HOPE-BE trial protocol and baseline demographic characteristics. ERJ Open Research. 2026; in press.

[2]. Fan J, et al. Dipeptidyl peptidase 1 inhibitor polymorph, preparation method and use therefor. WO2023160579A1. World Intellectual Property Organization. 2023-08-31.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Florensocatib

All Dipeptidyl Peptidase Isoforms