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  2. Hecogenin

Hecogenin 

Cat. No.: HY-N1422
Handling Instructions

Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects.

For research use only. We do not sell to patients.

Hecogenin Chemical Structure

Hecogenin Chemical Structure

CAS No. : 467-55-0

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Description

Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1].

IC50 & Target

Human UDP-glucuronosyltransferases[1]

In Vivo

Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1].

Animal Model: Male Swiss mice (20-30 g) with ethanol[1]
Dosage: 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg
Administration: Oral administration; for 15 hours
Result: Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.
Molecular Weight

430.62

Formula

C₂₇H₄₂O₄

CAS No.

467-55-0

SMILES
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

HecogeninOthersInhibitorinhibitorinhibit

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