1. Apoptosis
  2. Apoptosis
  3. Toddaculin

Toddaculin 

Cat. No.: HY-N9359
Handling Instructions

Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity.

For research use only. We do not sell to patients.

Toddaculin Chemical Structure

Toddaculin Chemical Structure

CAS No. : 4335-12-0

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Description

Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].

In Vitro

Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1].
Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

274.31

Formula

C₁₆H₁₈O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Toddaculin
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HY-N9359
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