4335-12-0
4335-12-0
Chemical Structure
Toddaculin
- CAS No.: 4335-12-0
- Formula:C16H18O4
- Molecular Weight:274.31
IUPAC Name: 5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
InChIKey: KRQHZFHWEAJPNO-UHFFFAOYSA-N
SMILES: O=C1C=CC2=C(OC)C(C/C=C(C)\C)=C(OC)C=C2O1
Biological Activity: Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Toddaculin | 99.73% | Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity. | ||||||||||||||||||||
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References
- [1]. Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46. [Content Brief]
- [2]. Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158. [Content Brief]
- [3]. Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137. [Content Brief]
Keywords
