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  3. Fenoprofen Calcium hydrate

Fenoprofen Calcium hydrate (Synonyms: Fenoprofen calcium salt dihydrate)

Cat. No.: HY-B0288B Purity: 99.35%
Handling Instructions

Fenoprofen Calcium hydrate is a nonsteroidal, anti-inflammatory antiarthritic agent.

For research use only. We do not sell to patients.

Fenoprofen Calcium hydrate Chemical Structure

Fenoprofen Calcium hydrate Chemical Structure

CAS No. : 71720-56-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
1 g USD 72 In-stock
Estimated Time of Arrival: December 31
5 g USD 108 In-stock
Estimated Time of Arrival: December 31
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50 g   Get quote  

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Other Forms of Fenoprofen Calcium hydrate:

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Description

Fenoprofen Calcium hydrate is a nonsteroidal, anti-inflammatory antiarthritic agent. Target: Prostaglandin G/H synthase 1 Fenoprofen is a non-steroidal anti-inflammatory, antipyretic, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout. Fenoprofen has a serum half-life of about 150 to 180 minutes and is at least 99% bound to plasma proteins. It is extensively metabolised after oral administration, the main metabolites being fenoprofen glucuronide and 4-hydroxy-fenoprofen glucuronide [1]. Fenoprofen calcium is revealed for relief of mild to moderate pain in adults and for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. In patients with osteoarthritis, the anti-inflammatory and analgesic effects of fenoprofen calcium have been demonstrated by decrease in tenderness as a response to pressure and reduction in night pain, stiffness, swelling, and overall disease activity. These effects have also been demonstrated by attenuation of pain with motion and at rest and increased range of motion in involved joints [2].

IC50 & Target[1]

COX

 

Molecular Weight

280.32

Formula

C₁₅H₁₄O₃.₁/₂Ca.H₂O

CAS No.

71720-56-4

SMILES

CC(C(O)=O)C1=CC(OC2=CC=CC=C2)=CC=C1.O.[0.5Ca2+]

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (356.74 mM)

H2O : 1 mg/mL (3.57 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5674 mL 17.8368 mL 35.6735 mL
5 mM 0.7135 mL 3.5674 mL 7.1347 mL
10 mM 0.3567 mL 1.7837 mL 3.5674 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.92 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.92 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Fenoprofen Calcium hydrate
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