Calcium propionate
Based on 1 Customer Validation
Calcium propionate (Propionic acid calcium) is a calcium salt of Propionic acid with oral activity, which can be hydrolyzed into propionate and calcium ions. Calcium propionate elevates intracellular ROS levels in tumor cells, depletes GSH, reduces mitochondrial membrane potential, and thereby induces tumor cell apoptosis. In mouse colitis models, Calcium propionate modulates inflammatory factors such as IFN-γ, calprotectin, and Pglyrp3, ameliorating intestinal inflammation and metabolic disorders. In ruminants, Calcium propionate serves as a gluconeogenic precursor, regulating rumen fermentation and microbial diversity; in high-fat diet rats, it alters gut microbiota composition and affects blood biochemical parameters. Calcium propionate is commonly used as a food and feed additive, and is also used in research related to hypocalcemia, dyslipidemia, colitis, and lung cancer.
For research use only. We do not sell to patients.
- Purity : 99.0%
- CAS No.: 4075-81-4
- Formula: (CH3CH2COO)2Ca
- Molecular Weight:186.22
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-B1580A
Calcium propionate, meets analytical specification of E282 -
HY-B1580AR
Calcium propionate, meets analytical specification of E282 (Standard) -
HY-B1580B
Calcium propionate, United States Pharmacopeia (USP) Reference Standard -
HY-N0626A
Potassium sorbate -
HY-B2227B
Lactic acid sodium (60% w/w in water) -
HY-112490
Atorvastatin calcium hydrate -
HY-Y1054
Magnesium stearate -
HY-N0626AR
Potassium sorbate (Standard) -
HY-B1529
Ammonium citrate dibasic, 99% -
HY-D0850
Tartaric acid disodium dihydrate -
HY-Y1054R
Magnesium stearate (Standard)
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
5.44 mg/mL
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Cytotoxicity against human A549 lung cancer cells assessed as reduction in cell viability after 24 hrs incubation by MTT assay.
Cytotoxicity against human A549 lung cancer cells assessed as reduction in cell viability after 24 hrs incubation by MTT assay.
|
tjb-2024-0054 |
| DMS-114 | IC50 |
12.15 mg/mL
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Cytotoxicity against human DMS114 lung cancer cells assessed as reduction in cell viability after 24 hrs incubation by MTT assay.
Cytotoxicity against human DMS114 lung cancer cells assessed as reduction in cell viability after 24 hrs incubation by MTT assay.
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tjb-2024-0054 |
In Vitro
Calcium propionate (0-16 mg/mL; 24 h) exerts dose-dependent cytotoxic effects on A549 lung cancer cells with an IC50 of 5.44 mg/mL, and inhibits DMS114 cells with an IC50 of 12.15 mg/mL, whereas Beas-2B normal lung cells maintain viability above 70% at all tested concentrations[5].
Calcium propionate (0-16 mg/mL; 24 h) increases intracellular ROS levels, with the most significant effect observed in A549 cells[5].
Calcium propionate (0.25-16 mg/mL; 24 h) significantly reduces intracellular GSH levels in A549 and DMS114 lung cancer cells, with the greatest reduction observed in A549 cells[5].
Calcium propionate (0.25-8 mg/mL; 24 h) significantly reduces the mitochondrial membrane potential in A549 and DMS114 lung cancer cells, with the greatest reduction observed in A549 cells[5].
Calcium propionate (0.25-8 mg/mL; 24 h) induces apoptosis in a dose-dependent manner, with the highest apoptosis rate observed in A549 lung cancer cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Calcium propionate (0.5-2.0% of food weight; p.o.; daily; 20 days) decreases relative spleen weight and increases relative kidney weight, induces moderate dyslipidemia and elevated De Ritis and Ca/P ratios, and significantly disrupts the gut microbiota by reducing Bifidobacterium and Lactobacillus while promoting Clostridium, Enterococcus, Klebsiella, and Candida, with antibacterial activity against Staphylococcus aureus[2].
Calcium propionate (100-300 g; p.o.; daily; from parturition to 63 days postpartum) improves the energy status of early-lactation dairy cows, with an optimal dose of approximately 200 g per cow per day[3].
Calcium propionate (3.85% w/v; drinking water; free access; 7 days) alleviates DSS-induced colitis in C57BL/6 mice, reduces liver weight, liver-to-body weight ratio, and abdominal fat, and decreases plasma IFN-γ and fecal calprotectin, while enhancing Pglyrp3[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 4075-81-4
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Appearance Solid
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Molecular Weight 186.22
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Formula (CH3CH2COO)2Ca
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Color White to off-white
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SMILES
CCC(O[Ca]C1(CC)OO1)=O
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Synonyms
Propionic acid calcium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (537.00 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
- Español - ES (615 KB)
- Swedish - SV (615 KB)
- Italian - IT (615 KB)
- Korean - KR (615 KB)
- Portuguese - PT (615 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.3700 mL | 26.8500 mL | 53.6999 mL | 134.2498 mL |
| 5 mM | 1.0740 mL | 5.3700 mL | 10.7400 mL | 26.8500 mL | |
| 10 mM | 0.5370 mL | 2.6850 mL | 5.3700 mL | 13.4250 mL | |
| 15 mM | 0.3580 mL | 1.7900 mL | 3.5800 mL | 8.9500 mL | |
| 20 mM | 0.2685 mL | 1.3425 mL | 2.6850 mL | 6.7125 mL | |
| 25 mM | 0.2148 mL | 1.0740 mL | 2.1480 mL | 5.3700 mL | |
| 30 mM | 0.1790 mL | 0.8950 mL | 1.7900 mL | 4.4750 mL | |
| 40 mM | 0.1342 mL | 0.6712 mL | 1.3425 mL | 3.3562 mL | |
| 50 mM | 0.1074 mL | 0.5370 mL | 1.0740 mL | 2.6850 mL | |
| 60 mM | 0.0895 mL | 0.4475 mL | 0.8950 mL | 2.2375 mL | |
| 80 mM | 0.0671 mL | 0.3356 mL | 0.6712 mL | 1.6781 mL | |
| 100 mM | 0.0537 mL | 0.2685 mL | 0.5370 mL | 1.3425 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Calcium propionate Related Classifications
HY-B1580 Related Classifications
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Keywords
- Calcium propionate
- 4075-81-4
- Propionic acid
- Biochemical Assay Reagents
- Bacterial
- IFNAR
- Apoptosis
- Reactive Oxygen Species (ROS)
- DSS-induced colitis
- rumen bacterial alpha diversity
- A549 lung cancer cells
- gluconeogenesis
- ruminal ammonia nitrogen
- rumen fermentation
- C57BL/6 mice
- DMS114 cells
- Beas-2B normal lung cells
- Inhibitor
- inhibitor
- inhibit