Calcium propionate, United States Pharmacopeia (USP) Reference Standard
Calcium propionate, United States Pharmacopeia (USP) Reference Standard (Bioban-C (Pharmaceutical primary standard, USP)) is a calcium salt of Propionic acid with oral activity, which can be hydrolyzed into propionate and calcium ions. Calcium propionate, United States Pharmacopeia (USP) Reference Standard elevates intracellular ROS levels in tumor cells, depletes GSH, reduces mitochondrial membrane potential, and thereby induces tumor cell apoptosis. In mouse colitis models, Calcium propionate, United States Pharmacopeia (USP) Reference Standard modulates inflammatory factors such as IFN-γ, calprotectin, and Pglyrp3, ameliorating intestinal inflammation and metabolic disorders. In ruminants, Calcium propionate, United States Pharmacopeia (USP) Reference Standard serves as a gluconeogenic precursor, regulating rumen fermentation and microbial diversity; in high-fat diet rats, it alters gut microbiota composition and affects blood biochemical parameters. Calcium propionate, United States Pharmacopeia (USP) Reference Standard is commonly used as a food and feed additive, and is also used in research related to hypocalcemia, dyslipidemia, colitis, and lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 4075-81-4
- Formula: C6H10CaO4
- Molecular Weight:186.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-B1580
Calcium propionate -
HY-B1580A
Calcium propionate, meets analytical specification of E282 -
HY-B1580AR
Calcium propionate, meets analytical specification of E282 (Standard) -
HY-N0626A
Potassium sorbate -
HY-B2227B
Lactic acid sodium (60% w/w in water) -
HY-112490
Atorvastatin calcium hydrate -
HY-Y1054
Magnesium stearate -
HY-N0626AR
Potassium sorbate (Standard) -
HY-B1529
Ammonium citrate dibasic, 99% -
HY-D0850
Tartaric acid disodium dihydrate -
HY-Y1054R
Magnesium stearate (Standard)
Biological Activity
Description
In Vitro
Calcium propionate, United States Pharmacopeia (USP) Reference Standard (0-16 mg/mL; 24 h) exerts dose-dependent cytotoxic effects on A549 lung cancer cells with an IC50 of 5.44 mg/mL, and inhibits DMS114 cells with an IC50 of 12.15 mg/mL, whereas Beas-2B normal lung cells maintain viability above 70% at all tested concentrations[5].
Calcium propionate, United States Pharmacopeia (USP) Reference Standard (0-16 mg/mL; 24 h) increases intracellular ROS levels, with the most significant effect observed in A549 cells[5].
Calcium propionate, United States Pharmacopeia (USP) Reference Standard (0.25-16 mg/mL; 24 h) significantly reduces intracellular GSH levels in A549 and DMS114 lung cancer cells, with the greatest reduction observed in A549 cells[5].
Calcium propionate, United States Pharmacopeia (USP) Reference Standard (0.25-8 mg/mL; 24 h) significantly reduces the mitochondrial membrane potential in A549 and DMS114 lung cancer cells, with the greatest reduction observed in A549 cells[5].
Calcium propionate, United States Pharmacopeia (USP) Reference Standard (0.25-8 mg/mL; 24 h) induces apoptosis in a dose-dependent manner, with the highest apoptosis rate observed in A549 lung cancer cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Calcium propionate, United States Pharmacopeia (USP) Reference Standard (0.5-2.0% of food weight; p.o.; daily; 20 days) decreases relative spleen weight and increases relative kidney weight, induces moderate dyslipidemia and elevated De Ritis and Ca/P ratios, and significantly disrupts the gut microbiota by reducing Bifidobacterium and Lactobacillus while promoting Clostridium, Enterococcus, Klebsiella, and Candida, with antibacterial activity against Staphylococcus aureus[2].
Calcium propionate, United States Pharmacopeia (USP) Reference Standard (100-300 g; p.o.; daily; from parturition to 63 days postpartum) improves the energy status of early-lactation dairy cows, with an optimal dose of approximately 200 g per cow per day[3].
Calcium propionate, United States Pharmacopeia (USP) Reference Standard (3.85% w/v; drinking water; free access; 7 days) alleviates DSS-induced colitis in C57BL/6 mice, reduces liver weight, liver-to-body weight ratio, and abdominal fat, and decreases plasma IFN-γ and fecal calprotectin, while enhancing Pglyrp3[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4075-81-4
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Molecular Weight 186.22
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Formula C6H10CaO4
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SMILES
CCC(O[Ca]C1(CC)OO1)=O
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Synonyms
Bioban-C (Pharmaceutical primary standard, USP)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Calcium propionate, United States Pharmacopeia (USP) Reference Standard Related Classifications
HY-B1580B Related Classifications
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Keywords
- Calcium propionate, United States Pharmacopeia (USP) Reference Standard
- 4075-81-4
- Bioban-C (Pharmaceutical primary standard, USP)
- Biochemical Assay Reagents
- Bacterial
- IFNAR
- Apoptosis
- Reactive Oxygen Species (ROS)
- DSS-induced colitis
- rumen bacterial alpha diversity
- A549 lung cancer cells
- Calcium propionate
- United States Pharmacopeia (USP) Reference Standard
- gluconeogenesis
- ruminal ammonia nitrogen
- rumen fermentation
- C57BL/6 mice
- DMS114 cells
- Beas-2B normal lung cells
- Inhibitor
- inhibitor
- inhibit