Antibacterial agent 121
Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 474099-18-8
- 分子式: C18H22N2O3S
- 分子量:346.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
15.3 μM
Compound: 10
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Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
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[PMID: 34890996] |
| RAW264.7 | IC50 |
4.1 μM
Compound: 10
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Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
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[PMID: 34890996] |
| RAW264.7 | IC50 |
80.2 μM
Compound: 10
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Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
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[PMID: 34890996] |
| RAW264.7 | CC50 |
≥200 μM
Compound: 10
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Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
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[PMID: 34890996] |
体外実験
Antibacterial agent 121 (0.2-200 µM; 24 h) inhibits M. tuberculosis H37Rv growth in bacterial culture[1].
Antibacterial agent 121 (0-200 µM; 24 h) inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC50 value of 4.1 µM[1].
Antibacterial agent 121 (6.25-200 µM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages[1].
Antibacterial agent 121 (25-100 µM, 4 d) inhibits M. tuberculosis M299 with an MIC50 value of 24.8 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:M. tuberculosis H37Rv
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Concentration:0.2-200 µM
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Incubation Time:24 hours
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Result:Inhibited Mtb H37Rv growth with MIC50 of 8.6 µM.
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Cell Line:RAW 264.7 macrophages and J774A.1 macrophages
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Concentration:6.25-200 µM
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Incubation Time:24 hours
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Result:Showed IC50 values of 15.3 µM and 28.4 µM for TNF-α and IL-1β production, respectively.
化学情報
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CAS 番号 474099-18-8
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分子量 346.44
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分子式 C18H22N2O3S
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SMILES
S=C(NC1=CC(OC)=C(OC)C(OC)=C1)NCCC2=CC=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antibacterial agent 121 関連分類
HY-151354 関連分類
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