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Cat. No.: HY-121594

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GSK-269984B

GSK-269984B is a potent EP1 antagonist. GSK-269984B has the potential for inflammatory pain research.

For research use only. We do not sell to patients.

CAS No.: 892664-17-4
Formula: C₂₀H₁₄Cl₂FNO₃
Molecular Weight:406.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

GSK-269984B Chemical Structure

CAS No.: 892664-17-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

GSK-269984B is a potent EP1 antagonist. GSK-269984B has the potential for inflammatory pain research^[1].

All Prostaglandin Receptor Isoforms :

Chemical Information

CAS No. 892664-17-4
Molecular Weight 406.23
Formula C₂₀H₁₄Cl₂FNO₃
SMILES

O=C(O)C1=NC(CC2=CC(Cl)=CC=C2OCC3=CC=C(C=C3F)Cl)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Formalin-Induced Paw Inflammation/Nociceptive Inflammation
The formalin-induced paw inflammation/nociceptive test is a chemical persistent pain model in rodents in which subcutaneous injection of formalin into the hind paw produces spontaneous nocifensive behaviors such as flinching and licking. The response is classically biphasic, consisting of an early acute phase (Phase I) reflecting direct activation of peripheral nociceptors (particularly C-fiber afferents), followed by a later prolonged phase (Phase II) associated with central sensitization in the spinal dorsal horn driven by sustained afferent input and inflammatory signaling. This model is widely used to evaluate analgesic and anti-inflammatory interventions because it captures both peripheral nociception and central sensitization processes within a single assay system.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Matthew Whiting, et al. Selection and Development of the Manufacturing Route for EP1 Antagonist GSK269984B. Org. Process Res. Dev. 2010, 14, 4, 820-831.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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