Chemerin-9 (149-157) TFA
Based on 4 publication(s) in Google Scholar
Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism.
For research use only. We do not sell to patients.
- Purity: 98.41%
- Formula: C56H67F3N10O15
- Molecular Weight:1177.18
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Chemerin-9 (149-157) TFA
MoreAll Chemerin Receptor Isoforms
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Biological Activity
Chemerin-9 (149-157) TFA (0.1 nM; 24 h; cardiac fibroblasts) stimulates migration in cardiac fibroblasts and stimulates phosphorylation of Akt and ERK as well as ROS production[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cardiac fibroblasts
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Concentration:0.1 nM
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Incubation Time:24 hours
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Result:Stimulated phosphorylation of Akt and ERK.
Chemerin-9 (149-157) TFA (7.7 μg /kg; i.h.; daily, for 28 days) has anti-inflammatory and anti-angiogenic effects in ApoE-/- mice and protects the abdominal aorta from MMP damage[2].
Chemerin-9 (149-157) TFA (8 μg/kg; ICV; daily; for 14 d; male Kunming mice) ameliorates Aβ1-42-induced memory impairment[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PDM mice[1]
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Dosage:0.2 mg/kg
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Administration:Intraperitoneal injection; daily, for 42 days
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Result:Increased expression of chemerin, GLUT2, and PDX1, which led to the alleviation of glucose intolerance and IR in PDM model mice.
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Animal Model:ApoE-/- mice[2]
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Dosage:7.7 μg /kg
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Administration:Subcutaneous injection; daily, for 28 days
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Result:Suppressed the enlargement of abdominal aorta and reversed the SMC loss.
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Animal Model:ApoE-/- mice[2]
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Dosage:7.7 μg /kg
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Administration:Subcutaneous injection; daily, for 28 days
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Result:Down-regulated MMP2 and MMP-9 expression and decreased the levels of chemerin and CMKLR1.
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Animal Model:Male Kunming mice[3]
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Dosage:8 μg/kg
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Administration:Intracerebroventrical injection; daily; for 14 days
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Result:Increased in the levels of pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the hippocampus.
Chemical Information
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Appearance Solid
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Molecular Weight 1177.18
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Formula C56H67F3N10O15
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Color White to off-white
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Sequence Shortening
YFPGQFAFS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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MedComm (2020)
Statins, but not proprotein convertase subtilisin-kexin type 9 inhibitors, lower chemerin in hypercholesterolemia via low-density lipoprotein receptor upregulation. [Abstract]2024 Aug 31;5(9):e681. PMID: 39220103 -
Hypertension
Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia. [Abstract]2024 Apr;81(4):861-875. PMID: 38361240 -
Eur J Pharmacol
Chemerin-9 in paraventricular nucleus increases sympathetic outflow and blood pressure via glutamate receptor-mediated ROS generation. [Abstract]2022 Dec 5:936:175343. PMID: 36306926 -
Eur J Neurosci
Chemerin in caudal division of nucleus tractus solitarius increases sympathetic activity and blood pressure. [Abstract]2024 Sep;60(5):4830-4842. PMID: 39044301
Solvent & Solubility
DMSO : ≥ 50 mg/mL (42.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 3.33 mg/mL (2.83 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Tu J, et, al. Regulatory effect of chemerin and therapeutic efficacy of chemerin 9 in pancreatogenic diabetes mellitus. Mol Med Rep. 2020 Mar;21(3):981-988. [Content Brief]
[2]. Chen S, et, al. Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE-/- Mice. J Oncol. 2021 Apr 17;2021:6629204. [Content Brief]
[3]. Lei Z, et, al. Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1-42-Induced Object Memory Impairment in Mice. Biol Pharm Bull. 2020 Feb 1;43(2):272-283. [Content Brief]
[4]. Yamamoto A, et, al. Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro. Eur J Pharmacol. 2021 Dec 5;912:174566. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.8495 mL | 4.2474 mL | 8.4949 mL | 21.2372 mL |
| DMSO | 5 mM | 0.1699 mL | 0.8495 mL | 1.6990 mL | 4.2474 mL |
| 10 mM | 0.0849 mL | 0.4247 mL | 0.8495 mL | 2.1237 mL | |
| 15 mM | 0.0566 mL | 0.2832 mL | 0.5663 mL | 1.4158 mL | |
| 20 mM | 0.0425 mL | 0.2124 mL | 0.4247 mL | 1.0619 mL | |
| 25 mM | 0.0340 mL | 0.1699 mL | 0.3398 mL | 0.8495 mL | |
| 30 mM | 0.0283 mL | 0.1416 mL | 0.2832 mL | 0.7079 mL | |
| 40 mM | 0.0212 mL | 0.1062 mL | 0.2124 mL | 0.5309 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Chemerin-9 (149-157) TFA Related Classifications
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