2. GPCR/G Protein PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Neuronal Signaling
  3. Chemerin Receptor Akt ERK Reactive Oxygen Species Amyloid-β
  4. Chemerin-9 (149-157) (TFA)

Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism.

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Chemerin-9 (149-157) (TFA) Chemical Structure

Chemerin-9 (149-157) (TFA) Chemical Structure

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 583 In-stock
Solution
10 mM * 1 mL in Water USD 583 In-stock
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1 mg USD 120 In-stock
5 mg USD 250 In-stock
10 mg USD 450 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Chemerin-9 (149-157) (TFA):

Chemerin-9 (149-157) (TFA) Related Antibodies

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2 Publications Citing Use of MCE Chemerin-9 (149-157) (TFA)

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism[1][2][3][4].

In Vitro

Chemerin-9 (149-157) TFA (0.1 nM; 24 h; cardiac fibroblasts) stimulates migration in cardiac fibroblasts and stimulates phosphorylation of Akt and ERK as well as ROS production[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemerin-9 (149-157) (TFA) Related Antibodies

Western Blot Analysis[4]

Cell Line: Cardiac fibroblasts
Concentration: 0.1 nM
Incubation Time: 24 hours
Result: Stimulated phosphorylation of Akt and ERK.
In Vivo

Chemerin-9 (149-157) TFA (0.2 mg/kg; i.p.; daily, for 42 days) alleviates glucose intolerance and IR in PDM mice[1].
Chemerin-9 (149-157) TFA (7.7 μg /kg; i.h.; daily, for 28 days) has anti-inflammatory and anti-angiogenic effects in ApoE-/- mice and protects the abdominal aorta from MMP damage[2].
Chemerin-9 (149-157) TFA (8 μg/kg; ICV; daily; for 14 d; male Kunming mice) ameliorates Aβ1-42-induced memory impairment[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PDM mice[1]
Dosage: 0.2 mg/kg
Administration: Intraperitoneal injection; daily, for 42 days
Result: Increased expression of chemerin, GLUT2, and PDX1, which led to the alleviation of glucose intolerance and IR in PDM model mice.
Animal Model: ApoE-/- mice[2]
Dosage: 7.7 μg /kg
Administration: Subcutaneous injection; daily, for 28 days
Result: Suppressed the enlargement of abdominal aorta and reversed the SMC loss.
Animal Model: ApoE-/- mice[2]
Dosage: 7.7 μg /kg
Administration: Subcutaneous injection; daily, for 28 days
Result: Down-regulated MMP2 and MMP-9 expression and decreased the levels of chemerin and CMKLR1.
Animal Model: Male Kunming mice[3]
Dosage: 8 μg/kg
Administration: Intracerebroventrical injection; daily; for 14 days
Result: Increased in the levels of pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the hippocampus.
Molecular Weight

1177.18

Formula

C56H67F3N10O15
Appearance

Solid

Color

White to off-white

Sequence Shortening

YFPGQFAFS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (84.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8495 mL 4.2474 mL 8.4949 mL
5 mM 0.1699 mL 0.8495 mL 1.6990 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8495 mL 4.2474 mL 8.4949 mL 21.2372 mL
5 mM 0.1699 mL 0.8495 mL 1.6990 mL 4.2474 mL
10 mM 0.0849 mL 0.4247 mL 0.8495 mL 2.1237 mL
15 mM 0.0566 mL 0.2832 mL 0.5663 mL 1.4158 mL
20 mM 0.0425 mL 0.2124 mL 0.4247 mL 1.0619 mL
25 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8495 mL
30 mM 0.0283 mL 0.1416 mL 0.2832 mL 0.7079 mL
40 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.5309 mL
50 mM 0.0170 mL 0.0849 mL 0.1699 mL 0.4247 mL
60 mM 0.0142 mL 0.0708 mL 0.1416 mL 0.3540 mL
80 mM 0.0106 mL 0.0531 mL 0.1062 mL 0.2655 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Chemerin-9 (149-157) (TFA) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chemerin-9 (149-157) (TFA)Chemerin ReceptorAktERKReactive Oxygen SpeciesAmyloid-βPKBProtein kinase BExtracellular signal regulated kinasesβ-amyloid peptideAβAbetaCMKLR1anti-inflammatoryimmune responsesadipocyte differentiationglucose metabolismInhibitorinhibitorinhibit

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