2. GPCR/G Protein PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Neuronal Signaling
  3. Chemerin Receptor Akt ERK Reactive Oxygen Species Amyloid-β
  4. Chemerin-9 (149-157)

Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism.

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Chemerin-9 (149-157) Chemical Structure

Chemerin-9 (149-157) Chemical Structure

CAS No. : 676367-27-4

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Chemerin-9 (149-157) Related Antibodies

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Description

Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism[1][2][3][4].

In Vitro

Chemerin-9 (149-157) (0.1 nM; 24 h; cardiac fibroblasts) stimulates migration in cardiac fibroblasts and stimulates phosphorylation of Akt and ERK as well as ROS production[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemerin-9 (149-157) Related Antibodies

Western Blot Analysis[4]

Cell Line: Cardiac fibroblasts
Concentration: 0.1 nM
Incubation Time: 24 hours
Result: Stimulated phosphorylation of Akt and ERK.
In Vivo

Chemerin-9 (149-157) (0.2 mg/kg; i.p.; daily, for 42 days) alleviates glucose intolerance and IR in PDM mice[1].
Chemerin-9 (149-157) (7.7  μg /kg; i.h.; daily, for 28 days) has anti-inflammatory and anti-angiogenic effects in ApoE-/- mice and protects the abdominal aorta from MMP damage[2].
Chemerin-9 (149-157) (8 μg/kg; ICV; daily; for 14 d; male Kunming mice) ameliorates Aβ1-42-induced memory impairment[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PDM mice[1]
Dosage: 0.2 mg/kg
Administration: Intraperitoneal injection; daily, for 42 days
Result: Increased expression of chemerin, GLUT2, and PDX1, which led to the alleviation of glucose intolerance and IR in PDM model mice.
Animal Model: ApoE-/- mice[2]
Dosage: 7.7 μg /kg
Administration: Subcutaneous injection; daily, for 28 days
Result: Suppressed the enlargement of abdominal aorta and reversed the SMC loss.
Animal Model: ApoE-/- mice[2]
Dosage: 7.7 μg /kg
Administration: Subcutaneous injection; daily, for 28 days
Result: Down-regulated MMP2 and MMP-9 expression and decreased the levels of chemerin and CMKLR1.
Animal Model: Male Kunming mice[3]
Dosage: 8 μg/kg
Administration: Intracerebroventrical injection; daily; for 14 days
Result: Increased in the levels of pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the hippocampus.
Molecular Weight

1063.16

Formula

C54H66N10O13
CAS No.
Sequence Shortening

YFPGQFAFS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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Chemerin-9 (149-157) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chemerin-9 (149-157)676367-27-4Chemerin ReceptorAktERKReactive Oxygen SpeciesAmyloid-βPKBProtein kinase BExtracellular signal regulated kinasesβ-amyloid peptideAβAbetaCMKLR1ROSanti-inflammatoryimmune responsesadipocyte differentiationglucose metabolismInhibitorinhibitorinhibit

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