Chemerin-9 (149-157)
Based on 4 publication(s) in Google Scholar
Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.57%
- CAS. Nr.: 676367-27-4
- Formel: C54H66N10O13
- Molecular Weight:1063.16
-
Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
Oxygen Sensing Compound Library
HY-L045
-
Glycolysis Compound Library
HY-L058
-
Cytoskeleton Compound Library
HY-L060
-
Glutamine Metabolism Compound Library
HY-L064
-
Anti-Alzheimer's Disease Compound Library
HY-L069
-
Anti-Breast Cancer Compound Library
HY-L074
-
Anti-Pancreatic Cancer Compound Library
HY-L077
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Neurodegenerative Disease-related Compound Library
HY-L086
-
Angiogenesis-Related Compound Library
HY-L088
-
Glucose Metabolism Compound Library
HY-L092
-
Peptide Library
HY-L105
-
Osteogenesis Compound Library
HY-L131
-
Heterocyclic Compound Library
HY-L138
-
Pain-Related Compound Library
HY-L139
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Protein Kinase Compound Library
HY-L196
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
Cell Proliferation Compound Library
HY-L201
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
-
GPCR/G Protein Compound Library
HY-L006
-
Immunology/Inflammation Compound Library
HY-L007
-
MAPK Compound Library
HY-L010
-
Metabolism/Protease Compound Library
HY-L012
-
Neuronal Signaling Compound Library
HY-L013
-
NF-κB Signaling Compound Library
HY-L014
-
PI3K/Akt/mTOR Compound Library
HY-L015
-
Stem Cell Signaling Compound Library
HY-L017
-
Autophagy Compound Library
HY-L029
-
Anti-Aging Compound Library
HY-L034
-
Peptide Compound Library
HY-L105S
Publications Citing Use of MedChemExpress (MCE) Chemerin-9 (149-157)
MoreAlle Chemerin Receptor Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Chemerin-9 (149-157) (0.1 nM; 24 h; cardiac fibroblasts) stimulates migration in cardiac fibroblasts and stimulates phosphorylation of Akt and ERK as well as ROS production[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Cardiac fibroblasts
-
Concentration:0.1 nM
-
Incubation Time:24 hours
-
Result:Stimulated phosphorylation of Akt and ERK.
Chemerin-9 (149-157) (7.7 μg /kg; i.h.; daily, for 28 days) has anti-inflammatory and anti-angiogenic effects in ApoE-/- mice and protects the abdominal aorta from MMP damage[2].
Chemerin-9 (149-157) (8 μg/kg; ICV; daily; for 14 d; male Kunming mice) ameliorates Aβ1-42-induced memory impairment[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:PDM mice[1]
-
Dosage:0.2 mg/kg
-
Administration:Intraperitoneal injection; daily, for 42 days
-
Result:Increased expression of chemerin, GLUT2, and PDX1, which led to the alleviation of glucose intolerance and IR in PDM model mice.
-
Animal Model:ApoE-/- mice[2]
-
Dosage:7.7 μg /kg
-
Administration:Subcutaneous injection; daily, for 28 days
-
Result:Suppressed the enlargement of abdominal aorta and reversed the SMC loss.
-
Animal Model:ApoE-/- mice[2]
-
Dosage:7.7 μg /kg
-
Administration:Subcutaneous injection; daily, for 28 days
-
Result:Down-regulated MMP2 and MMP-9 expression and decreased the levels of chemerin and CMKLR1.
-
Animal Model:Male Kunming mice[3]
-
Dosage:8 μg/kg
-
Administration:Intracerebroventrical injection; daily; for 14 days
-
Result:Increased in the levels of pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the hippocampus.
Chemical Information
-
CAS. Nr. 676367-27-4
-
Appearance Solid
-
Molecular Weight 1063.16
-
Formel C54H66N10O13
-
Color White to off-white
-
Sequence Shortening
YFPGQFAFS
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
-
Journal Impact Factor
-
Most Recent
-
MedComm (2020)
Statins, but not proprotein convertase subtilisin-kexin type 9 inhibitors, lower chemerin in hypercholesterolemia via low-density lipoprotein receptor upregulation. [Abstract]2024 Aug 31;5(9):e681. PMID: 39220103 -
Hypertension
Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia. [Abstract]2024 Apr;81(4):861-875. PMID: 38361240 -
Eur J Pharmacol
Chemerin-9 in paraventricular nucleus increases sympathetic outflow and blood pressure via glutamate receptor-mediated ROS generation. [Abstract]2022 Dec 5:936:175343. PMID: 36306926 -
Eur J Neurosci
Chemerin in caudal division of nucleus tractus solitarius increases sympathetic activity and blood pressure. [Abstract]2024 Sep;60(5):4830-4842. PMID: 39044301
Lösungsmittel & Löslichkeit
H2O : 10 mg/mL (9.41 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (283 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Tu J, et, al. Regulatory effect of chemerin and therapeutic efficacy of chemerin 9 in pancreatogenic diabetes mellitus. Mol Med Rep. 2020 Mar;21(3):981-988. [Content Brief]
[2]. Chen S, et, al. Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE-/- Mice. J Oncol. 2021 Apr 17;2021:6629204. [Content Brief]
[3]. Lei Z, et, al. Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1-42-Induced Object Memory Impairment in Mice. Biol Pharm Bull. 2020 Feb 1;43(2):272-283. [Content Brief]
[4]. Yamamoto A, et, al. Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro. Eur J Pharmacol. 2021 Dec 5;912:174566. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9406 mL | 4.7030 mL | 9.4059 mL | 23.5148 mL |
| 5 mM | 0.1881 mL | 0.9406 mL | 1.8812 mL | 4.7030 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Chemerin-9 (149-157) Related Classifications
HY-P1844 Related Classifications
Powered by Bioz