Chemerin-9 (149-157)
Based on 4 publication(s) in Google Scholar
Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1). Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism.
For research use only. We do not sell to patients.
- Purity : 99.65%
- CAS No.: 676367-27-4
- Formula: C54H66N10O13
- Molecular Weight:1063.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Chemerin-9 (149-157)
MoreAll Chemerin Receptor Isoforms
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Biological Activity
Description
In Vitro
Chemerin-9 (149-157) (0.1 nM; 24 h; cardiac fibroblasts) stimulates migration in cardiac fibroblasts and stimulates phosphorylation of Akt and ERK as well as ROS production[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cardiac fibroblasts
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Concentration:0.1 nM
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Incubation Time:24 hours
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Result:Stimulated phosphorylation of Akt and ERK.
In Vivo
Chemerin-9 (149-157) (7.7 μg /kg; i.h.; daily, for 28 days) has anti-inflammatory and anti-angiogenic effects in ApoE-/- mice and protects the abdominal aorta from MMP damage[2].
Chemerin-9 (149-157) (8 μg/kg; ICV; daily; for 14 d; male Kunming mice) ameliorates Aβ1-42-induced memory impairment[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PDM mice[1]
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Dosage:0.2 mg/kg
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Administration:Intraperitoneal injection; daily, for 42 days
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Result:Increased expression of chemerin, GLUT2, and PDX1, which led to the alleviation of glucose intolerance and IR in PDM model mice.
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Animal Model:ApoE-/- mice[2]
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Dosage:7.7 μg /kg
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Administration:Subcutaneous injection; daily, for 28 days
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Result:Suppressed the enlargement of abdominal aorta and reversed the SMC loss.
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Animal Model:ApoE-/- mice[2]
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Dosage:7.7 μg /kg
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Administration:Subcutaneous injection; daily, for 28 days
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Result:Down-regulated MMP2 and MMP-9 expression and decreased the levels of chemerin and CMKLR1.
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Animal Model:Male Kunming mice[3]
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Dosage:8 μg/kg
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Administration:Intracerebroventrical injection; daily; for 14 days
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Result:Increased in the levels of pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the hippocampus.
- Kinase activity and phosphorylation assays
- Western Blot
- 3T3-L1 preadipocyte-to-adipocyte differentiation
- Cotton Pellet Granuloma
- ROS/oxidative-stress fluorescent staining
- Carrageenan-Induced Paw Edema
- Large-size fat particle sorting
- Research Protocol for Inflammation-related Diseases
- Protocol for Kinase activity and phosphorylation assays
Chemical Information
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CAS No. 676367-27-4
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Appearance Solid
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Molecular Weight 1063.16
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Formula C54H66N10O13
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Color White to off-white
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Sequence Shortening
YFPGQFAFS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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MedComm (2020)
Statins, but not proprotein convertase subtilisin-kexin type 9 inhibitors, lower chemerin in hypercholesterolemia via low-density lipoprotein receptor upregulation. [Abstract]2024 Aug 31;5(9):e681. PMID: 39220103 -
Hypertension
Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia. [Abstract]2024 Apr;81(4):861-875. PMID: 38361240 -
Eur J Pharmacol
Chemerin-9 in paraventricular nucleus increases sympathetic outflow and blood pressure via glutamate receptor-mediated ROS generation. [Abstract]2022 Dec 5:936:175343. PMID: 36306926 -
Eur J Neurosci
Chemerin in caudal division of nucleus tractus solitarius increases sympathetic activity and blood pressure. [Abstract]2024 Sep;60(5):4830-4842. PMID: 39044301
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (94.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 10 mg/mL (9.41 mM; Need ultrasonic)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (297 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Tu J, et, al. Regulatory effect of chemerin and therapeutic efficacy of chemerin 9 in pancreatogenic diabetes mellitus. Mol Med Rep. 2020 Mar;21(3):981-988. [Content Brief]
[2]. Chen S, et, al. Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE-/- Mice. J Oncol. 2021 Apr 17;2021:6629204. [Content Brief]
[3]. Lei Z, et, al. Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1-42-Induced Object Memory Impairment in Mice. Biol Pharm Bull. 2020 Feb 1;43(2):272-283. [Content Brief]
[4]. Yamamoto A, et, al. Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro. Eur J Pharmacol. 2021 Dec 5;912:174566. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.9406 mL | 4.7030 mL | 9.4059 mL | 23.5148 mL |
| 5 mM | 0.1881 mL | 0.9406 mL | 1.8812 mL | 4.7030 mL | |
| DMSO | 10 mM | 0.0941 mL | 0.4703 mL | 0.9406 mL | 2.3515 mL |
| 15 mM | 0.0627 mL | 0.3135 mL | 0.6271 mL | 1.5677 mL | |
| 20 mM | 0.0470 mL | 0.2351 mL | 0.4703 mL | 1.1757 mL | |
| 25 mM | 0.0376 mL | 0.1881 mL | 0.3762 mL | 0.9406 mL | |
| 30 mM | 0.0314 mL | 0.1568 mL | 0.3135 mL | 0.7838 mL | |
| 40 mM | 0.0235 mL | 0.1176 mL | 0.2351 mL | 0.5879 mL | |
| 50 mM | 0.0188 mL | 0.0941 mL | 0.1881 mL | 0.4703 mL | |
| 60 mM | 0.0157 mL | 0.0784 mL | 0.1568 mL | 0.3919 mL | |
| 80 mM | 0.0118 mL | 0.0588 mL | 0.1176 mL | 0.2939 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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