1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Enoximone

Enoximone 

Cat. No.: HY-B1639
Handling Instructions

Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects.

For research use only. We do not sell to patients.

Enoximone Chemical Structure

Enoximone Chemical Structure

CAS No. : 77671-31-9

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10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
25 mg USD 320 In-stock
Estimated Time of Arrival: December 31
50 mg USD 580 In-stock
Estimated Time of Arrival: December 31
100 mg USD 980 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects[1][2][3].

IC50 & Target[1]

PDE3/PDE Ⅲ

5.9 μM (IC50)

PDE4A

21.1 μM (IC50, myocardial PDE4A)

In Vitro

In vitro, 10 μM Enoximone-treated bronchoalveolar lavage (BAL) eosinophils induced by IL-33 treatment shows significantly lower CD11b expression when compared with diluent-treated BAL eosinophils[1].

In Vivo

Topical Enoximone (25 μg; intratracheal route) abrogates house dust mite (HDM)-induced allergic airway inflammation[1].
The Enoximone-treated (25 μg; for 5 days) HDM-exposed mice shows significant reductions in inflammatory cell numbers including eosinophils, macrophages, neutrophils, ILC2s, and T cells, indicating that Enoximone treatment reduces airway inflammation[1].

Molecular Weight

248.30

Formula

C₁₂H₁₂N₂O₂S

CAS No.

77671-31-9

SMILES

O=C1NC(C)=C(C(C2=CC=C(SC)C=C2)=O)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (33.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0274 mL 20.1369 mL 40.2739 mL
5 mM 0.8055 mL 4.0274 mL 8.0548 mL
10 mM 0.4027 mL 2.0137 mL 4.0274 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

EnoximonePhosphodiesterase (PDE)AntiasthmacAMPPDE3airwayanti-inflammatoryCD11beosinophilsvasodilatingbronchodilatoryPDE4AInhibitorinhibitorinhibit

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Enoximone
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HY-B1639
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