77671-31-9
Chemical Structure
Enoximone
- CAS No.: 77671-31-9
- Formula:C12H12N2O2S
- Molecular Weight:248.30
IUPAC Name: 4-methyl-5-(4-(methylthio)benzoyl)-1,3-dihydro-2H-imidazol-2-one
InChIKey: ZJKNESGOIKRXQY-UHFFFAOYSA-N
SMILES: O=C1NC(C)=C(N1)C(C2=CC=C(C=C2)SC)=O
Biological Activity: Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects[1][2][3].
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Enoximone | 99.91% | Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects. | ||||||||||||||||||||
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- [1]. Jan Beute, et al. A Pathophysiological Role of PDE3 in Allergic Airway Inflammation. JCI Insight. 2018 Jan 25;3(2):e94888. [Content Brief]
- [2]. R C Dage, et al. Pharmacology and Pharmacokinetics of Enoximone. Cardiology. 1990;77 Suppl 3:2-13; discussion 27-33. [Content Brief]
- [3]. M B Vroom, et al. Effect of Phosphodiesterase Inhibitors on Human Arteries in Vitro. Br J Anaesth. 1996 Jan;76(1):122-9. [Content Brief]
Keywords
