1. Autophagy
  2. Autophagy
  3. BRD5631

BRD5631 

Cat. No.: HY-125197
Handling Instructions

BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production.

For research use only. We do not sell to patients.

BRD5631 Chemical Structure

BRD5631 Chemical Structure

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Description

BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production[1].

IC50 & Target

Autophagy[1]

In Vitro

BRD5631 (10 μM, 48 hours) leads to increased levels of LC3-II in HeLa cells. BRD5631 stimulates formation of new autophagosomes, which is consistent with its ability to increase numbers of autolysosomes in the mCherry-GFP-LC3 assay[1].
BRD5631 does not enhance autophagy by directly inhibiting mTOR or the mTOR signaling pathway. BRD5631 suppressed IL-1β secretion in an autophagy-dependent manner[1].

Cell Viability Assay[1]

Cell Line: HeLa cells.
Concentration: 10 μM.
Incubation Time: 48 hours.
Result: Led to increased levels of LC3-II.
Molecular Weight

501.62

Formula

C₃₀H₃₅N₃O₄

SMILES

O=C(NC1=CC=C2C(C(N(C[[email protected]@H](OC)[[email protected]@H](C)CN[[email protected]@H](C)CO2)C)=O)=C1)C3=CC=C(C4=CC=CC=C4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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BRD5631
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