2. Autophagy
  3. Autophagy
  4. BRD5631

BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production.

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BRD5631 Chemical Structure

BRD5631 Chemical Structure

CAS No. : 2446154-91-0

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BRD5631 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BRD5631

IF

    BRD5631 purchased from MedChemExpress. Usage Cited in: Cancer Gene Ther. 2022 Dec 9.  [Abstract]

    Both HLY78 and BRD5631 significantly abrogate the effects of miR-219-5p on SKOV3 and SKOV3/DDP cell invasion (fig E) and migration (fig F).

    BRD5631 purchased from MedChemExpress. Usage Cited in: Cancer Gene Ther. 2022 Dec 9.  [Abstract]

    Both HLY78 and BRD5631 significantly abrogate the effect of miR-219-5p on SKOV3 and SKOV3/DDP cell apoptosis.

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    Description

    BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production[1].

    IC50 & Target

    Autophagy[1]
    In Vitro

    BRD5631 (10 μM, 48 hours) leads to increased levels of LC3-II in HeLa cells. BRD5631 stimulates formation of new autophagosomes, which is consistent with its ability to increase numbers of autolysosomes in the mCherry-GFP-LC3 assay[1].
    BRD5631 does not enhance autophagy by directly inhibiting mTOR or the mTOR signaling pathway. BRD5631 suppressed IL-1β secretion in an autophagy-dependent manner[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    BRD5631 Related Antibodies

    Cell Viability Assay[1]

    Cell Line: HeLa cells.
    Concentration: 10 μM.
    Incubation Time: 48 hours.
    Result: Led to increased levels of LC3-II.
    Molecular Weight

    501.62

    Formula

    C30H35N3O4
    CAS No.
    SMILES

    O=C(NC1=CC=C2C(C(N(C[C@@H](OC)[C@@H](C)CN[C@@H](C)CO2)C)=O)=C1)C3=CC=C(C4=CC=CC=C4)C=C3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    BRD5631 Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    BRD56312446154-91-0BRD 5631BRD-5631AutophagyInhibitorinhibitorinhibit

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