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(-)-DHMEQ

(Synonyms: Dehydroxymethylepoxyquinomicin)
35 Cited Publications
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Based on 35 publication(s) in Google Scholar

(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity.

For research use only. We do not sell to patients.

  • Purity: 99.81%
  • CAS No.: 287194-40-5
  • Formula: C13H11NO5
  • Molecular Weight:261.23
  • Storage:

    -20°C, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

  • (-)-DHMEQ Chemical Structure
    (-)-DHMEQ Chemical Structure
  • Experimental Validation Results for (-)-DHMEQ
  • Experimental Validation Results for (-)-DHMEQ
  • Experimental Validation Results for (-)-DHMEQ
  • Experimental Validation Results for (-)-DHMEQ
  • Experimental Validation Results for (-)-DHMEQ
CAS No.: 287194-40-5
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • (-)-DHMEQ Chemical Structure
    (-)-DHMEQ Chemical Structure
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    (-)-DHMEQ purchased from MedChemExpress. Usage Cited in: Mol Cells. 2018 Dec 31;41(12):1008-1015. [Abstract]

    Customer Validation
     NCI-H157 cells are pretreated with DHMEQ (10 or 20 μg/mL) for 2 h and then stimulated with PS-341 for 6 or 24 h. Nuclear proteins (6 h) and whole cell proteins (24 h) are isolated and subjected to Western blot analysis for p65, Lamin A/C, COX-2, and GAPDH.

  • 1/16

    (-)-DHMEQ purchased from MedChemExpress. Usage Cited in: Mol Cancer Ther. 2018 Jun;17(6):1303-1314. [Abstract]

    Customer Validation
     Effects of TNF-α/DHMEQ on the expression of NF-κB and AR as well as neoplastic transformation of urothelial cells. Western blotting of NF-κB/p65, p-NF-κB/p65, and AR, using proteins extracted from SVHUC-AR cells cultured with ethanol, TNF-α(20 ng/mL), or DHMEQ (15 µg/mL) for 6 hours.

  • 1/16

    (-)-DHMEQ purchased from MedChemExpress. Usage Cited in: Mol Cancer Ther. 2018 Jun;17(6):1303-1314. [Abstract]

    Customer Validation
     Effects of NF-κB activation/inhibition on the expression of NF-κB and its downstream targets as well as AR in bladder cancer cells. Western blotting of NF-κB/p65, p-NF-κB/p65, and AR, using proteins extracted from UMUC3 cells cultured with ethanol (mock), TNF-α (20 ng/mL), or DHMEQ (15 µg/mL) for 6 hours.

  • 1/16

    (-)-DHMEQ purchased from MedChemExpress. Usage Cited in: Biol Pharm Bull. 2017;40(10):1669-1677. [Abstract]

    Customer Validation
     A549 transfectants stably expressing RelB WT (A) are preincubated with various concentrations of (–)-DHMEQ for 1 h and then incubated with or without LTβ (25 ng/mL) for 2 h in the presence or absence of (−)-DHMEQ.

  • 1/16

    (-)-DHMEQ purchased from MedChemExpress. Usage Cited in: Biol Pharm Bull. 2017;40(10):1669-1677. [Abstract]

    Customer Validation
     A549 transfectants stably expressing RelB (C144S) (B) are preincubated with various concentrations of (–)-DHMEQ for 1 h and then incubated with or without LTβ (25 ng/mL) for 2 h in the presence or absence of (−)-DHMEQ.

  • (-)-DHMEQ