2. NF-κB
  3. Keap1-Nrf2
  4. (+)-DHMEQ

(+)-DHMEQ  (Synonyms: (1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ)

Cat. No.: HY-14645A Purity: 99.33%
COA Handling Instructions

(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.

For research use only. We do not sell to patients.

(+)-DHMEQ Chemical Structure

(+)-DHMEQ Chemical Structure

CAS No. : 287194-41-6

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 241 In-stock
Solution
10 mM * 1 mL in DMSO USD 241 In-stock
Solid
2 mg USD 168 In-stock
5 mg USD 264 In-stock
10 mg USD 360 In-stock
25 mg USD 720 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of (+)-DHMEQ:

(+)-DHMEQ Related Antibodies

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  • Biological Activity

  • Protocol

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  • References

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Description

(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.

IC50 & Target

Nrf2[1]
In Vitro

(+)-DHMEQ ((2R,3R,4R)-DHMEQ) activates Nrf2, which is a transcription factor that induces the expression of multiple antioxidant enzymes. (+)-DHMEQ activates Nrf2 in a promoter reporter assay. (+)-DHMEQ also increases the expression of target antioxidant proteins and cancelled reactive oxygen species (ROS)-induced cell death in a neuronal cell line. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(+)-DHMEQ Related Antibodies
Molecular Weight

261.23

Appearance

Solid

Formula

C13H11NO5
CAS No.
SMILES

O=C(NC([C@@H](O)[C@@]1([H])O[C@@]21[H])=CC2=O)C3=CC=CC=C3O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (382.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8280 mL 19.1402 mL 38.2804 mL
5 mM 0.7656 mL 3.8280 mL 7.6561 mL
10 mM 0.3828 mL 1.9140 mL 3.8280 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.57 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
Cell Assay
[1]

SK-N-SH cells are seeded at 1.75×104 cells/well in a 24-well plate and cultured overnight. The cells are treated with various concentrations of (+)-DHMEQ (1, 3, and 10 μg/mL) for 24 h and subsequently treated with 300 μM 6-OHDA for 24 h. Then, cells are stained with Trypan blue, and the number of stained cells is counted[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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(+)-DHMEQ Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

(+)-DHMEQ287194-41-6(1R,2R,6R)-Dehydroxymethylepoxyquinomicin (1R,2R,6R)-DHMEQKeap1-Nrf2Inhibitorinhibitorinhibit

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