1. NF-κB
  2. NF-κB

(+)-DHMEQ (Synonyms: (1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ)

Cat. No.: HY-14645A Purity: 98.02% ee.: 99.69%
Data Sheet SDS Handling Instructions

The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-κB.

For research use only. We do not sell to patients.
(+)-DHMEQ Chemical Structure

(+)-DHMEQ Chemical Structure

CAS No. : 287194-41-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $201 In-stock
2 mg $140 In-stock
5 mg $220 In-stock
10 mg $300 In-stock
25 mg $600 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Other Forms of (+)-DHMEQ:

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  • References

Description

The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-κB. In vitro: (+)-DHMEQ down-regulat the NF-κB target genes IRF4 and CD40, the secretion of IL-6, CCL5, CCL17 and generated ROS. Cytotoxicity, CD30 down-modulation and CD30 shedding by (+)-DHMEQ are prevented by ROS scavenger NAC. [1] (+)-DHMEQ is a novel NF-κB inhibitor that induces apoptosis and cell-cycle arrest in several cancer cell types and promotes ROS generation, which causes genotoxic DNA damage in human liver cells. [2]

References
Molecular Weight

261.23

Formula

C₁₃H₁₁NO₅

CAS No.

287194-41-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 35 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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(+)-DHMEQ
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HY-14645A
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