1. NF-κB
  2. Keap1-Nrf2

(+)-DHMEQ (Synonyms: (1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ)

Cat. No.: HY-14645A Purity: 98.02% ee.: 99.69%
Handling Instructions

(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.

For research use only. We do not sell to patients.

(+)-DHMEQ Chemical Structure

(+)-DHMEQ Chemical Structure

CAS No. : 287194-41-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 241 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
2 mg USD 168 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 264 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 360 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 720 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Other Forms of (+)-DHMEQ:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.

IC50 & Target

Nrf2[1]

In Vitro

(+)-DHMEQ ((2R,3R,4R)-DHMEQ) activates Nrf2, which is a transcription factor that induces the expression of multiple antioxidant enzymes. (+)-DHMEQ activates Nrf2 in a promoter reporter assay. (+)-DHMEQ also increases the expression of target antioxidant proteins and cancelled reactive oxygen species (ROS)-induced cell death in a neuronal cell line. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.8280 mL 19.1402 mL 38.2804 mL
5 mM 0.7656 mL 3.8280 mL 7.6561 mL
10 mM 0.3828 mL 1.9140 mL 3.8280 mL
Please refer to the solubility information to select the appropriate solvent.
Cell Assay
[1]

SK-N-SH cells are seeded at 1.75×104 cells/well in a 24-well plate and cultured overnight. The cells are treated with various concentrations of (+)-DHMEQ (1, 3, and 10 μg/mL) for 24 h and subsequently treated with 300 μM 6-OHDA for 24 h. Then, cells are stained with Trypan blue, and the number of stained cells is counted[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

261.23

Formula

C₁₃H₁₁NO₅

CAS No.

287194-41-6

SMILES

O=C(NC([[email protected]@H](O)[[email protected]@]1([H])O[[email protected]@]21[H])=CC2=O)C3=CC=CC=C3O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 35 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
(+)-DHMEQ
Cat. No.:
HY-14645A
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