1. NF-κB
  2. NF-κB
  3. DHMEQ racemate

DHMEQ racemate (Synonyms: rel-DHMEQ)

Cat. No.: HY-14645B
Handling Instructions

DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ.

For research use only. We do not sell to patients.

DHMEQ racemate Chemical Structure

DHMEQ racemate Chemical Structure

CAS No. : 287194-38-1

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DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ.

IC50 & Target[1]



In Vitro

DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate[1].

In Vivo

The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it[1].

Molecular Weight







O=C1[[email protected]]2[[email protected]](O2)[[email protected]](O)C(NC(C3=C(O)C=CC=C3)=O)=C1.O=C4[[email protected]@H](O5)[[email protected]@H]5[[email protected]@H](O)C(NC(C6=C(O)C=CC=C6)=O)=C4.[relative stereochemistry]


Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (122.50 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8280 mL 19.1402 mL 38.2804 mL
5 mM 0.7656 mL 3.8280 mL 7.6561 mL
10 mM 0.3828 mL 1.9140 mL 3.8280 mL
*Please refer to the solubility information to select the appropriate solvent.
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DHMEQ racematerel-DHMEQNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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