1. Anti-infection
  2. Bacterial

Minocycline hydrochloride 

Cat. No.: HY-17412 Purity: 99.61%
Data Sheet SDS Handling Instructions

Minocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects.

For research use only. We do not sell to patients.
Minocycline hydrochloride Chemical Structure

Minocycline hydrochloride Chemical Structure

CAS No. : 13614-98-7

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    Minocycline hydrochloride purchased from MCE. Usage Cited in: Neurochem Res. 2017 Apr 22.

    a Statistical analysis showing the prevention effect of minocycline pretreatment (40 mg/kg/day) on CUS-, CRS- or CSDS-induced decreases in hippocampal microglial numbers. b, c Statistical analysis showing the prevention effect of minocycline pretreatment (40 mg/kg/day) on CUS-, CRS- or CSDS-induced increases in the immobile time in the TST (b) and FST (c).
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Minocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. IC50 Value: N/A Target: Antibacterial Minocycline acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Minocycline also inhibit the enzymatic activity of poly(ADP-ribose) polymerase-1 (PARP-1) and angiogenesis. In addition, Minocycline is suggested to down-regulate CD40L on T cells and inhibit the replication of SIV and HIV. Orally active and brain penetrant.

    Clinical Trial
    NCT Number Sponsor Condition Start Date Phase
    NCT02201563 University of Pittsburgh Irradiation; Adverse Effect November 2015 Phase 1
    NCT01429272 Laureate Institute for Brain Research, Inc.|Stanley Medical Research Institute|University of Oklahoma Bipolar Disorder Depression September 2011 Phase 3
    NCT01514422 Icahn School of Medicine at Mount Sinai Bipolar Depression May 2011 Phase 4
    NCT02808052 Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)|Universitätsklinikum Köln|The Medicines Company|Innovative Medicines Initiative Renal Insufficiency, Acute|Renal Insufficiency, Chronic|Healthy Subjects May 29, 2017 Phase 1
    NCT01493622 Central South University Schizophrenia June 2010 Phase 4
    NCT02178813 University of Pittsburgh Stroke July 2014 Phase 1
    NCT00418392 National Taiwan University Hospital Pneumothorax November 2006 Phase 3
    NCT02802631 Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)|Universitätsklinikum Köln|The Medicines Company|Innovative Medicines Initiative Normal Healthy Volunteers April 20, 2017 Phase 1
    NCT00666887 Dr. Luanne Metz|Multiple Sclerosis Society of Canada|University of Calgary Clinically Isolated Syndromes|Early Single Relapse of Multiple Sclerosis January 2009 Phase 3
    NCT01805895 Augusta University|American Heart Association Intracerebral Hemorrhage February 2013 Phase 1|Phase 2
    NCT00668746 OraPharma Periodontitis December 2007 Phase 4
    NCT01561742 The University of Texas Health Science Center, Houston|Stanley Medical Research Institute Schizophrenia February 2012
    NCT01779089 Los Angeles Biomedical Research Institute Diabetic Nephropathy February 2009
    NCT00536042 State University of New York - Downstate Medical Center Asthma October 1997 Phase 2
    NCT03050086 BioPharmX, Inc. Moderate to Severe Papulopustular Rosacea March 29, 2017 Phase 1|Phase 2
    NCT02541500 University of Science Malaysia|Yale University Heroin Dependence|Amphetamine Dependence April 2013 Phase 3
    NCT02695446 BioPharmX, Inc. Acne March 2016 Phase 4
    NCT02140164 National Eye Institute (NEI)|The EMMES Corporation|National Institutes of Health Clinical Center (CC) Retinitis Pigmentosa May 2014 Phase 1|Phase 2
    NCT01403662 University Health Network, Toronto Bipolar Disorder|Bipolar Depression|Bipolar I Depression|Bipolar II Depression July 2011 Phase 3
    NCT03160040 Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company) Gram-Negative Bacterial Infections June 1, 2017
    NCT00240513 Derm Research @ 888 Inc.|Stiefel, a GSK Company Acne Vulgaris August 2004 Phase 4
    NCT00277355 Merit Cudkowicz|FDA Office of Orphan Products Development|Huntington Study Group Huntington Disease April 2006 Phase 2|Phase 3
    NCT00456677 State University of New York - Downstate Medical Center Asthma June 1996 Phase 2
    NCT01433055 University of Maryland|National Institute of Mental Health (NIMH) Schizophrenia July 2011
    NCT01422148 Baystate Medical Center Atrial Fibrillation October 2011
    NCT01659320 Weill Medical College of Cornell University|National Institute of Mental Health (NIMH) Depression March 2012
    NCT02533232 Pakistan Institute of Learning and Living Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder August 2015 Phase 1
    NCT02056665 Puerta de Hierro University Hospital Angelman Syndrome January 2014 Phase 2
    NCT01297816 Shahid Beheshti University of Medical Sciences Retinal Detachment December 2010 Phase 2
    NCT01120899 National Eye Institute (NEI)|The EMMES Corporation|National Institutes of Health Clinical Center (CC) Diabetic Macular Edema April 2010 Phase 1|Phase 2
    NCT01574742 Shalvata Mental Health Center Unipolar Depression June 2012 Phase 1
    NCT02213575 University of Florida|National Heart, Lung, and Blood Institute (NHLBI) Hypertension May 2017 Phase 1
    NCT02263872 Pakistan Institute of Learning and Living|King's College London Depressive Disorder|Mood Disorders|Depressive Disorder, Treatment Resistant|Antidepressive Agents October 2014 Phase 4
    NCT00855062 Johns Hopkins University|Makerere University HIV-associated Cognitive Impairment|HIV Infections April 2008 Phase 1|Phase 2
    NCT02680379 Université de Sherbrooke|FRAXA Research Foundation Fragile X Syndrome March 2016 Phase 2
    NCT01938508 GlaxoSmithKline|CECYC (Center of Scientific and Clinical Studies, CRO) Skin Diseases May 2013 Phase 1
    NCT01755611 GlaxoSmithKline Skin Infections (Acne) June 17, 2011 Phase 1
    NCT00401921 Brigham and Women's Hospital Carotid Stenosis October 2006 Phase 2
    NCT00409747 National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) Autism|Minocycline|Regressive Autism November 2006 Phase 4
    NCT02055963 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Head And Neck Cancer May 2014 Phase 2
    NCT02928965 University of Manchester|University of Edinburgh|University of Cambridge|University College, London|University of Birmingham|King's College London|Manchester Mental Health & Social Care Trust|Greater Manchester West Mental Health NHS Foundation Trust|Salford Royal NHS Foundation Trust|Lancashire Care NHS Foundation Trust|Cambridgeshire and Peterborough NHS Foundation Trust|West London Mental Health NHS Trust|North East London Foundation Trust|Central and North West London NHS Foundation Trust|Camden and Islington NHS Foundation Trust|South London and Maudsley NHS Foundation Trust|NHS Lothian|NHS Fife|NHS Borders|University Hospital Birmingham NHS Foundation Trust Schizophrenia and Disorders With Psychotic Features February 2013 Phase 2
    NCT01468844 National Eye Institute (NEI)|National Institutes of Health Clinical Center (CC) Retinal Vein Occlusion September 26, 2011 Phase 1|Phase 2
    NCT01314482 University of Adelaide Post-operative Intercostal Neuralgia November 2010 Phase 2
    NCT01636934 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Lung Cancer July 2012 Phase 2
    NCT01053156 University of California, Davis|The National Fragile X Foundation Fragile X Syndrome January 2010
    NCT01531582 University of South Florida Angelman Syndrome April 2012
    NCT00203112 Teva Pharmaceutical Industries Relapse Remitting Multiple Sclerosis June 2004 Phase 2
    NCT02187211 Yale University|United States Department of Defense Alcohol Dependence July 2015 Phase 1
    NCT00836355 New York University School of Medicine|James N. Kirby Foundation Acute Ischemic Stroke April 2009
    NCT01647282 University of Nebraska Moderate to Advanced Chronic Periodontitis September 2012 Phase 4
    NCT01468831 National Eye Institute (NEI)|National Institutes of Health Clinical Center (CC) Retinal Vein Occlusion September 19, 2011 Phase 1|Phase 2
    NCT01083420 Sheba Medical Center Oral Lichen Planus March 2010 Phase 3
    NCT00858689 FRAXA Research Foundation|Fragile X Research Foundation of Canada Fragile X Syndrome October 2007
    NCT03040128 University of Tennessee Health Science Center|University of Southern California Intracerebral Hemorrhage June 27, 2013 Phase 1|Phase 2
    NCT02359006 Yale University Opioid Dependence|Pain March 2015
    NCT01813240 Hadassah Medical Organization Spinal Tumors, Trauma Patients, Minocycline. May 2013 Phase 2|Phase 3
    NCT02968602 University of Maryland|National Institute on Drug Abuse (NIDA) Schizophrenia|Tobacco Use March 31, 2017 Phase 4
    NCT02312609 Ranbaxy Laboratories Limited|Ranbaxy Inc. Healthy September 2008
    NCT02312297 Ranbaxy Laboratories Limited|Ranbaxy Inc. Healthy September 2008
    NCT00777413 Ranbaxy Laboratories Limited|Ranbaxy Inc. Healthy November 2002
    NCT00776542 Ranbaxy Laboratories Limited|Ranbaxy Inc. Healthy October 2002
    NCT02272270 University of Utah Newly Diagnosed High Grade Glioma October 2014 Phase 1
    NCT00988026 Darier Mild to Moderate Acne June 2009 Phase 4
    NCT00733057 Shalvata Mental Health Center|Abarbanel Mental Health Center Negative and Cognitive Symptoms in Schizophrenia August 2003 Phase 3
    NCT01058395 Wayne State University Traumatic Brain Injury February 2010 Phase 1|Phase 2
    NCT03117530 University of California, Los Angeles Autism Spectrum Disorder April 1, 2017 Phase 1
    NCT02456948 Charite University, Berlin, Germany Major Depressive Disorder December 2015 Phase 2
    NCT02124811 Emory University Schizophrenia|Schizoaffective Disorder February 2015 Phase 4
    NCT01064752 University of California, San Francisco HIV Infection April 2005
    NCT02907437 Beer Yaakov and Ness Ziona Mental Health Center|Bar-Ilan University, Israel Schizophrenia January 2015 Phase 3
    NCT02928692 RenJi Hospital|Shanghai 10th People's Hospital|Pudong New Area People's Hospital|Shanghai Pudong Hospital|Shanghai Pudong New Aera Dongming Community Health Care Center Prostate Cancer|Carcinoma of the Rectum|Colon Cancer|Renal Carcinoma July 2015 Phase 3
    NCT00930020 Singhealth Foundation|National Neuroscience Institute|Changi General Hospital Acute Stroke July 2009 Phase 4
    NCT02250859 Foamix Ltd. Acne September 2014 Phase 1
    NCT01809158 Addis Ababa University|Stanley Medical Research Institute Schizophrenia April 2013 Phase 4
    NCT00916461 Stanley Medical Research Institute|Rawalpindi Medical College, Pakistan|Pakistan Institute of Learning and Living|University of Sao Paulo First Episode Psychosis May 2006 Phase 1|Phase 2
    NCT02051296 VA Palo Alto Health Care System Chronic Pain|Post-operative Pain January 2012 Phase 2
    NCT02564978 National Eye Institute (NEI)|National Institutes of Health Clinical Center (CC) Age- Related Macular Degeneration September 17, 2015 Phase 2
    NCT02193269 Yale University Memory Impairment July 2013
    NCT00630396 David Hess, MD|National Institute of Neurological Disorders and Stroke (NINDS)|University of Kentucky|Oregon Health and Science University|Augusta University Stroke, Acute May 2008 Phase 1|Phase 2
    NCT01173692 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Oropharynx Cancer July 2010 Phase 2
    NCT01539564 OraPharma Peri-Implantitis April 2012 Phase 3
    NCT01809340 Janssen Research & Development, LLC Depressive Disorder June 2013 Phase 2
    NCT00579644 University of Nebraska Rheumatoid Arthritis January 2001 Phase 3
    NCT00630942 Mayo Clinic Primary Sclerosing Cholangitis February 2003 Phase 1
    NCT01517334 OraPharma Peri-Implantitis May 2012 Phase 3
    NCT01828203 Rick Hansen Institute|University of Calgary|Alberta Paraplegic foundation Spinal Cord Injuries June 2013 Phase 3
    NCT01134627 Merck KGaA Multiple Sclerosis, Relapsing-Remitting February 2006 Phase 2
    NCT02355977 Zhejiang University|Academic Centre for Dentistry in Amsterdam Chronic Periodontitis June 2013 Phase 4
    NCT01906008 M.D. Anderson Cancer Center|American Cancer Society, Inc. Colorectal Cancer November 2013 Phase 2
    NCT00765336 Medicis Pharmaceutical Corporation Human Volunteer November 2006 Phase 4
    NCT00556491 Tarek M. El-Achkar|Satellite Healthcare|Triax Pharmaceuticals|St. Louis University Kidney Failure, Acute|Acute Kidney Insufficiency December 2007
    NCT00154895 National Taiwan University Hospital|National Science Council, Taiwan Pneumothorax June 2001 Phase 3
    NCT02946788 BioPharmX, Inc. Acne Vulgaris March 13, 2017 Phase 2
    NCT01463384 Huntington Medical Research Institutes Mild Cognitive Impairment|Alzheimer's Disease September 2011 Phase 2
    NCT02297412 Academic and Community Cancer Research United|National Cancer Institute (NCI) Acute Pain|Breast Carcinoma|Peripheral Neuropathy November 2014
    NCT01600625 Yonsei University Meibomian Gland Dysfunction November 2011
    NCT01695291 New York State Psychiatric Institute|National Institute of Mental Health (NIMH)|Weill Medical College of Cornell University Obsessive Compulsive Disorder May 2012 Phase 2
    NCT01073813 University of Calgary|Neuroscience Canada Multiple Sclerosis|Optic Neuritis February 2010 Phase 2
    NCT00559494 University of Calgary|Paralyzed Veterans of America|American Association of Neurological Surgeons|Hotchkiss Brain Institute, University of Calgary Spinal Cord Injuries June 2004 Phase 1|Phase 2
    NCT02133872 University of Florida|National Heart, Lung, and Blood Institute (NHLBI) Hypertension October 2014 Phase 1
    NCT02569307 Pakistan Institute of Learning and Living At Risk Mental State (ARMS)|Psychosis October 2015 Phase 2
    NCT02203552 Ohio State University Comprehensive Cancer Center Anxiety Disorder|Depression|Recurrent Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer June 2015
    NCT00047723 National Institute of Neurological Disorders and Stroke (NINDS) Amyotrophic Lateral Sclerosis January 2003 Phase 3
    NCT00029874 FDA Office of Orphan Products Development Huntington's Disease September 2001 Phase 1|Phase 2
    NCT02030912 Helperby Therapeutics Ltd|Richmond Pharmacology Limited Antibiotic Resistant Bacteria December 2009 Phase 4
    NCT00145106 KGL, Inc.|Milton S. Hershey Medical Center|State University of New York - Downstate Medical Center|Jefferson Medical College of Thomas Jefferson University|New York University School of Medicine|Allergan Acne Vulgaris March 2002 Phase 4
    NCT01869907 Ziekenhuis Oost-Limburg Neuropathic Pain Caused by Lumbar Radicular Pain September 2011 Phase 4
    NCT00361257 AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID)|Neurologic AIDS Research Consortium (NARC) HIV Infections March 2007 Phase 2
    NCT01693523 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Pancreatic Cancer January 2013 Phase 2
    NCT00203697 University of California, Los Angeles Idiopathic Pulmonary Fibrosis Phase 3
    NCT02719392 Massachusetts General Hospital Bipolar Disorder|Bipolar Depression September 2016 Phase 4
    NCT02712775 Medical University of South Carolina Liver Disease March 2016 Phase 4
    NCT01171326 Foamix Ltd. Impetigo August 2010 Phase 2
    NCT01317550 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Lung Cancer July 2011
    NCT00839553 Far Eastern Memorial Hospital|National Taiwan University Hospital|Department of Health Pneumothorax April 2007
    NCT02133885 University of Florida|National Heart, Lung, and Blood Institute (NHLBI) Hypertension December 2016 Phase 1|Phase 2
    NCT01746043 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Esophageal Cancer February 2013 Phase 2
    NCT02815332 BioPharmX, Inc. Acne Vulgaris August 2016 Phase 2
    NCT01134991 Foamix Ltd. Rosacea June 2010 Phase 2
    NCT01320982 Sheba Medical Center Schizophrenia|Schizoaffective Disorder March 2011 Phase 3
    NCT02703363 Pakistan Institute of Learning and Living|Dow University of Health Sciences|Abbasi Shaheed Hospital|Rawalpindi Medical College, Pakistan|University of Manchester|Stanley Medical Research Institute Depression|Bipolar Disorder|Bipolar Depression|Mood Disorders August 2016 Phase 3
    NCT00270751 National Taiwan University Hospital|National Science Council, Taiwan Pneumothorax April 2005 Phase 2|Phase 3
    NCT01133080 Shalvata Mental Health Center Schizophrenia June 2010 Phase 4
    NCT02113176 University at Buffalo|University at Buffalo Neurosurgery Subarachnoid Aneurysm Hemorrhage January 2010 Phase 1|Phase 2
    NCT01283997 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Myeloma January 2011 Phase 2
    NCT01580969 University of Utah Recurrent Glioma July 2012 Phase 1|Phase 2
    NCT00392223 Pfizer Acne Vulgaris October 2007 Phase 3
    NCT02765100 Weill Medical College of Cornell University|Weill Cornell Medical College in Qatar Bipolar Disorder|Depression|Obesity October 2014
    NCT01793051 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Myeloma March 2013 Phase 2
    NCT02060149 Xijing Hospital Pneumonia March 2014 Phase 1|Phase 2
    NCT02998151 Children's Hospital Medical Center, Cincinnati|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fragile X Syndrome January 2016 Phase 2
    NCT02362529 Centre for Addiction and Mental Health Major Depressive Disorder February 2015 Early Phase 1
    NCT00529555 Sunstar Americas Adult Periodontitis January 2006 Phase 3
    NCT00662532 OraPharma Periodontitis April 2008 Phase 3
    NCT00378781 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Cancer
    NCT00063193 University of Rochester|National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease May 2003 Phase 2
    NCT03106740 Marco Loggia|National Institute of Neurological Disorders and Stroke (NINDS)|Massachusetts General Hospital Low Back Pain|Back Pain With Radiation|Back Pain Without Radiation|Back Pain Lower Back Chronic|Back Ache|Pain, Chronic May 2017 Phase 2
    NCT02815280 Foamix Ltd. Acne Vulgaris May 2016 Phase 3
    NCT02815267 Foamix Ltd. Acne Vulgaris May 2016 Phase 3
    NCT01206348 Medicis Global Service Corporation Acne September 2010 Phase 4
    NCT00355576 Columbia University|ALS Association|Pfizer Amyotrophic Lateral Sclerosis July 2006 Phase 2
    NCT00243893 University of California, San Francisco|National Institute of Neurological Disorders and Stroke (NINDS) Aneurysms|Arteriovenous Malformations July 2004 Phase 1
    NCT00371332 OraPharma Periodontitis January 2004 Phase 3
    NCT01362010 Foamix Ltd. Acne Vulgaris January 2012 Phase 2
    NCT01802216 University of California, San Francisco Chronic Kidney Disease|Periodontal Disease February 2014
    NCT01219673 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Head And Neck Cancer March 2013 Phase 1|Phase 2
    NCT00473083 British Columbia Cancer Agency|Hoffmann-La Roche Rash January 2009 Phase 2
    NCT02618317 University of Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo Chronic Kidney Disease July 2013 Phase 4
    NCT00515255 Neuropharm Obsessive Compulsive Disorder July 2007 Phase 2
    NCT02947763 Cairo University Periapical Periodontitis November 2016 Phase 1
    NCT01048983 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Non Small Cell Lung Cancer Phase 1|Phase 2
    NCT00294502 Henry Ford Health System ESRD September 2003 Phase 4
    NCT00893724 Mid-Atlantic Retina Consultations, Inc.|West Virginia University Neovascular Age-related Macular Degeneration|Diabetic Macular Edema June 2009
    NCT01029717 Institute of Child Health Catheter-Related Infections January 2010 Phase 3
    NCT02515955 Janssen-Cilag International NV Healthy August 2015 Phase 1
    NCT01349192 University of North Carolina, Chapel Hill|CF Therapeutics Development Network Coordinating Center|Seattle Children's Hospital|Washington University School of Medicine|University of Washington|University of Colorado, Denver|Baylor College of Medicine|University of Alabama at Birmingham|Cook Children's Medical Center|University of Michigan|University of Florida|University of Texas Southwestern Medical Center|Children's Hospital Medical Center, Cincinnati|St. Louis Children's Hospital Cystic Fibrosis|Methicillin-resistant Staphylococcus Aureus April 2011 Phase 2
    NCT02770378 University of Ulm|Reliable Cancer Therapies|Anticancer Fund, Belgium Glioblastoma November 2016 Phase 1
    NCT02913118 Qingfeng Pharmaceutical Group Community Acquired Pneumonia July 2016 Phase 4
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    References
    Molecular Weight

    493.94

    Formula

    C₂₃H₂₈ClN₃O₇

    CAS No.

    13614-98-7

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    H2O: 2.45 mg/mL; DMSO: 0.49 mg/mL

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

    Purity: 99.61%

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    Product Name:
    Minocycline hydrochloride
    Cat. No.:
    HY-17412
    Quantity: