Hirsutenone
Based on 1 Customer Validation
Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.74%
- No. CAS: 41137-87-5
- Fòrmula: C19H20O5
- Peso molecular:328.36
-
Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-10115
PI-103PI3K/mTOR Inhibitor -
HY-N0284
EsculetinPI3K Inhibitor -
HY-N6950
Hederacolchiside A1Antischistosomal Agent -
HY-10115A
PI-103 HydrochloridePI3K/mTOR Inhibitor -
HY-13334
BGT226 maleate -
HY-10372
PP121Multi-targeted Kinase Inhibitor -
HY-12868
BimiralisibPI3K/mTOR Inhibitor -
HY-10344
AZD 6482PI3Kβ Inhibitor -
HY-N0284R
Esculetin (Standard)PI3K Inhibitor -
HY-10115R
PI-103 (Standard)PI3K/mTOR Inhibitor -
HY-10372R
PP121 (Standard)Reference Standard -
HY-10115AR
PI-103 Hydrochloride (Standard)PI3K/mTOR Inhibitor
Actividad biológica
Descripciòn
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
220 μM
Compound: 42
|
Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay
Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay
|
[PMID: 20004045] |
| HSC-T6 | IC50 |
14 μM
Compound: 2
|
Antifibrotic activity against rat HSC-T6 cells assessed as inhibition of proliferation after 48 hrs by BrdU incorporation assay
Antifibrotic activity against rat HSC-T6 cells assessed as inhibition of proliferation after 48 hrs by BrdU incorporation assay
|
[PMID: 21504848] |
| RAW264.7 | IC50 |
>100 μM
Compound: 34
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kappaB activation incubated for 24 hrs by SEAP microplate reader analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kappaB activation incubated for 24 hrs by SEAP microplate reader analysis
|
[PMID: 33422907] |
| RAW264.7 | IC50 |
>100 μM
Compound: 34
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis
|
[PMID: 33422907] |
| RAW264.7 | IC50 |
>100 μM
Compound: 34
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 1 hr followed by LPS stimulation and measured after 18 hrs by immunoassay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 1 hr followed by LPS stimulation and measured after 18 hrs by immunoassay
|
[PMID: 33422907] |
| RAW264.7 | IC50 |
0.8 μM
Compound: 34
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess method
|
[PMID: 33422907] |
| RAW264.7 | IC50 |
14.1 μM
Compound: 34
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method
|
[PMID: 33422907] |
| RAW264.7 | IC50 |
25 μg/mL
Compound: 34
|
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
|
[PMID: 33422907] |
| RAW264.7 | IC50 |
27.2 μg/mL
Compound: 34
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 24 hrs by Griess assay
|
[PMID: 33422907] |
| RAW264.7 | IC50 |
39 μM
Compound: 34
|
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by MTT assay
|
[PMID: 33422907] |
| RAW264.7 | IC50 |
5 μM
Compound: 34
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 0.5 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 0.5 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
|
[PMID: 33422907] |
| RAW264.7 | IC50 |
5.8 μM
Compound: 34
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
|
[PMID: 33422907] |
In Vitro
Hirsutenone (0-100 μM; 48 hours) inhibits adipogenesis in 3T3-L1 preadipocytes and exhibits non-toxicity at 20-100 μM[1]. Hirsutenone (0-100 μM; 48 hours) attenuates MDI-induced lipid accumulation in 3T3-L1 preadipocytes in a dose-dependent manner. In particular, HST at 40 and 80 μM significantly reduces MDI-induced adipogenesis in 3T3-L1 preadipocytes[1].Hirsutenone (0-100 μM; 48 hours) reduces the protein expression levels of PPARg, C/EBPa, and FAS in a dose-dependent manner in 3T3-L1 preadipocytes[1].Hirsutenone (80 μM; 20-24 hours) suppresses the cell cycle entry to S and G2/M phases occurrs at 20 hours when compares with at 20 hours. At 24 h, more cells are arrested in G1 phase (53% of total cells) when compares with the MDI-induced group which contains the majority of cells (56% of total cells) in G2/M phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 41137-87-5
-
Appearance Solid
-
Peso molecular 328.36
-
Fòrmula C19H20O5
-
Color White to off-white
-
SMILES
OC1=C(O)C=CC(CC/C=C/C(CCC2=CC(O)=C(O)C=C2)=O)=C1
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
-
Ficha de datos (264 KB)
-
SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hirsutenone Related Classifications
HY-N4042 Related Classifications
Powered by Bioz