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Cyclopyrimorate, a highly effective bleaching herbicide for weed control in rice fields, targets homogentisate solanesyltransferase (HST). HST is a downstream enzyme of 4-hydroxyphenylpyruvate dioxygenase in the plastoquinone (PQ) biosynthesis pathway .
Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity .
Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC50 value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases .
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases .
Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity .
FGF-4 Protein orchestrates embryonic development, cell proliferation, and differentiation, crucial for normal limb and cardiac valve development. FGF-4 may contribute to embryonic molar tooth bud development by inducing key gene expressions. Engaging with FGFRs, FGF-4 forms molecular alliances vital for signaling cascades. The potentiated binding affinity with heparan sulfate glycosaminoglycans serves as indispensable coreceptors, highlighting the multifaceted and essential role of FGF-4 in fundamental developmental processes. FGF-4 Protein, Human (136a.a) is the recombinant human-derived FGF-4 protein, expressed by E. coli, with tag free. The total length of FGF-4 Protein, Human (136a.a) is 136 a.a., with molecular weight of ~16 kDa.
FGF-4 Protein orchestrates embryonic development, cell proliferation, and differentiation, crucial for normal limb and cardiac valve development. FGF-4 may contribute to embryonic molar tooth bud development by inducing key gene expressions. Engaging with FGFRs, FGF-4 forms molecular alliances vital for signaling cascades. The potentiated binding affinity with heparan sulfate glycosaminoglycans serves as indispensable coreceptors, highlighting the multifaceted and essential role of FGF-4 in fundamental developmental processes. Animal-Free FGF-4 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-4 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free FGF-4 Protein, Human (His) is 182 a.a., with molecular weight of ~20.70 kDa.
FGF-4 Protein, Human (166a.a) is a member of the FGF family that transforms 3T3 cells with high efficiency, stimulates endothelial cell proliferation, migration, and protease production, and shows angiogenic activity.
The FGF-4 protein plays a key role in embryonic development and is central to cell proliferation and differentiation. It is essential for the survival of mouse embryos after implantation and is key to normal limb and heart valve development. FGF-4 Protein, Mouse is the recombinant mouse-derived FGF-4 protein, expressed by E. coli , with tag free. The total length of FGF-4 Protein, Mouse is 136 a.a., with molecular weight of ~15 kDa.
The SULT2A1 protein utilizes PAPS for critical sulfonation of steroids and bile acids in the liver and adrenal glands. Its multifunctional activity extends to a variety of compounds, enhancing its water solubility to facilitate renal excretion. SULT2A1 Protein, Human (His) is the recombinant human-derived SULT2A1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SULT2A1 Protein, Human (His) is 284 a.a., with molecular weight of 34-38 kDa.
The FGF-4 protein coordinates embryonic development, cell proliferation and differentiation and is critical for normal limb and heart valve development. FGF-4 may promote embryonic molar tooth bud development by inducing key gene expression. FGF-4 Protein, Human (153a.a) is the recombinant human-derived FGF-4 protein, expressed by E. coli , with tag free. The total length of FGF-4 Protein, Human (153a.a) is 153 a.a., with molecular weight of ~16.0 kDa.
FGF-6 Protein orchestrates cell proliferation, differentiation, angiogenesis, and myogenesis, crucial for normal muscle regeneration. Interacting with FGFR1, FGFR2, and FGFR4, it mediates signaling cascades impacting various cellular processes. The presence of heparan sulfate glycosaminoglycans enhances FGF-6's affinity with fibroblast growth factors and receptors. FGF-6 Protein's multifaceted actions underscore its significance in coordinating essential cellular events, playing a vital role in tissue development, angiogenesis, and the intricate process of muscle regeneration. Animal-Free FGF-6 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-6 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free FGF-6 Protein, Human (His) is 168 a.a., with molecular weight of ~19.66 kDa.
The MFG-E8 protein plays a critical role in promoting the phagocytic clearance of apoptotic cells in various tissues. As a specific ligand, it interacts with alpha-v/beta-3 and alpha-v/beta-5 receptors and also binds independently to phosphatidylserine-rich cell surfaces. MFG-E8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MFG-E8 protein, expressed by HEK293 , with N-His labeled tag. The total length of MFG-E8 Protein, Mouse (HEK293, His) is 441 a.a., with molecular weight of 60-70 kDa.
SIRT1 is an NAD-dependent protein deacetylase that integrates multiple cellular functions—cell cycle progression, DNA damage response, metabolism, apoptosis, and autophagy—by regulating the acetylation of various target proteins. SIRT1 responds to changes in the NAD(+)/NADH ratio caused by factors such as glucose deprivation, affecting chromatin remodeling through histone deacetylation, resulting in transcriptional regulation. SIRT1 Protein, Human (555a.a, His) is the recombinant human-derived SIRT1 protein, expressed by E. coli , with N-His labeled tag. The total length of SIRT1 Protein, Human (555a.a, His) is 555 a.a., with molecular weight of ~62.8 kDa.
Siglec-15 Protein, a Siglec family member and type-1 transmembrane protein, is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. Siglec-15 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived Siglec-15 protein, expressed by HEK293 , with C-His labeled tag. The total length of Siglec-15 Protein, Mouse (Biotinylated, HEK293, His) is 239 a.a., with molecular weight of 35-43 kDa.
Siglec-15 Protein, a Siglec family member and type-1 transmembrane protein, is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. Siglec-15 Protein, Cynomolgus (HEK293, His-Avi) is the recombinant cynomolgus-derived Siglec-15 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of Siglec-15 Protein, Cynomolgus (HEK293, His-Avi) is 244 a.a., with molecular weight of 33-43 kDa.
Siglec-15 protein plays a crucial role in cellular interactions, selectively binding to sialylated glycoproteins with an affinity for sialic acid residues. Engaging with TYROBP and HCST, it indicates involvement in intricate signaling pathways. This specific recognition of sialylated glycoproteins underscores Siglec-15's significance in mediating immune responses and cellular communication, contributing to the complex network of cellular interactions. Siglec-15 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Siglec-15 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of Siglec-15 Protein, Human (HEK293, His-Avi) is 244 a.a., with molecular weight of 30-38 kDa.
The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Cynomolgus (Biotinylated, 263a.a, HEK293, His-Avi) is the recombinant cynomolgus-derived Siglec-15 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Siglec-15 Protein, Cynomolgus (Biotinylated, 263a.a, HEK293, His-Avi) is 263 a.a., with molecular weight of 33-43 kDa.
CA12 (or carbonic anhydrase 12) plays a crucial role in the reversible hydration of carbon dioxide, catalyzing its conversion into bicarbonate ions and protons. This enzymatic activity is essential for key physiological processes, including regulating pH and maintaining acid-base balance. CA12/Carbonic Anhydrase 12 Protein, Human (P.pastoris, His) is the recombinant human-derived CA12/Carbonic Anhydrase 12 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of CA12/Carbonic Anhydrase 12 Protein, Human (P.pastoris, His) is 277 a.a., with molecular weight of ~33.1 kDa.
SIRT1 is an NAD-dependent protein deacetylase that integrates multiple cellular functions—cell cycle progression, DNA damage response, metabolism, apoptosis, and autophagy—by regulating the acetylation of various target proteins. SIRT1 responds to changes in the NAD(+)/NADH ratio caused by factors such as glucose deprivation, affecting chromatin remodeling through histone deacetylation, resulting in transcriptional regulation. SIRT1 Protein, Human (746a.a, His) is the recombinant human-derived SIRT1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SIRT1 Protein, Human (746a.a, His) is 746 a.a., with molecular weight of ~90 kDa.
Thymidylate Synthase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to thymidylate synthase. It can be used for WB, IHC-F, IHC-P, ICC/IF, IP assays with tag free, in the background of Human.
