FGF-6 Protein, Human
Based on 1 Customer Validation
FGF-6 Protein, Human is a potent mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
FGF-6 Protein, Human is a potent mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells.
Fibroblast growth factor 6 (FGF-6) is a heparin-binding member of the FGF family, which are regulators of cell proliferation, differentiation, and function. FGF-6 binds and signals through the FGF receptors 1c, 2c, and 4[1]. FGF-6 is a potent mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells[2].
The ED50 is <2.5 ng/mL as measured by 3T3 cells, corresponding to a specific activity of >4.0 × 105 units/mg.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P10767 (G41-I208)
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Molecular Construction
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N-term
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FGF-6 (G41-I208)
Accession # P10767 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
FGF6; FGF-6; Fibroblast Growth Factor 6; HST-2; Heparin Secretory-Transforming Protein 2; HST2; Heparin-Binding Growth Factor 6; Fibroblast Growth Factor; HBGF-6; HSTF2; HSTF-2; FGF
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AA Sequence
GTRANNTLLDSRGWGTLLSRSRAGLAGEIAGVNWESGYLVGIKRQRRLYCNVGIGFHLQVLPDGRISGTHEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATPSFQEECKFRETLLPNNYNAYESDLYQGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI
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Molecular Weight
Approximately 19 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS.
<0.2 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Ornitz DM, et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996 Jun 21;271(25):15292-7. [Content Brief]
[2]. Ropiquet F, et al. Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. Cancer Res. 2000 Aug 1;60(15):4245-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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