1. NF-κB
    Immunology/Inflammation
    Cell Cycle/DNA Damage
  2. NF-κB
    COX
    PPAR
  3. Adelmidrol

Adelmidrol 

Cat. No.: HY-B1026 Purity: >98.0%
Handling Instructions

Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol reduces NF-κB translocation, and COX-2 expression.

For research use only. We do not sell to patients.

Adelmidrol Chemical Structure

Adelmidrol Chemical Structure

CAS No. : 1675-66-7

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Description

Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol reduces NF-κB translocation, and COX-2 expression.

IC50 & Target[1]

NF-κB

 

COX-2

 

PPARγ

 

In Vitro

Adelmidrol is a palmitoylethanolamide analogue. Adelmidrol reduces NF-κB translocation, COX-2, and p-ERK expression; proinflammatory cytokine release; and the incidence of nitrotyrosine and poly(ADP)ribose in the colon[1].

In Vivo

Adelmidrol (10 mg/kg, o.s.) reduces significantly the degree and severity of the macroscopic and histologic signs of colon injury. Moreover, 4 days after colitis induced by dinitrobenzene sulfonic acid (DNBS) treatment, all mice have diarrhea and a reduction in body weight (compared with the sham groups). Adelmidrol (10 mg/kg, o.s.) treatment significantly reduces the loss of body weight. The inflammatory bowel disease (IBD) induced by DNBS intrarectally administered is also characterized by an augmentation in myeloperoxidase (MPO) activity, an indicator of neutrophil accumulating in the colon. This is consistent with light microscopic observations showing the colon of vehicle-treated DNBS mice to contain a large number of neutrophils. In contrast, Adelmidrol (10 mg/kg, o.s.) significantly reduces the degree of polymorphonuclear cell infiltration (determined as reduction in MPO activity) in inflamed colon[1].

Clinical Trial
Molecular Weight

274.36

Formula

C₁₃H₂₆N₂O₄

CAS No.

1675-66-7

SMILES

O=C(NCCO)CCCCCCCC(NCCO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (123.92 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6448 mL 18.2242 mL 36.4485 mL
5 mM 0.7290 mL 3.6448 mL 7.2897 mL
10 mM 0.3645 mL 1.8224 mL 3.6448 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
Male adult CD1 mice (25-30 g) and male mice (20-27 g) are placed in a controlled environment and maintained on a 12-hour light/dark cycle with food and water available ad libitum. Mice are casually divided into the following groups (10 in each group) (1)Sham+vehicle group: Vehicle solution (saline) is given by oral administration for 4 days. (2) Sham+Adelmidrol (10 mg/kg): Administered o.s. for 4 days. (3) DNBS+vehicle: Mice are injected by DNBS as described, and vehicle (saline) is given o.s. each day for 4 days, starting 60 minutes after the injection of DNBS. (4) DNBS+Adelmidrol (10 mg/kg): Mice are injected by DNBS as described, and Adelmidrol (10 mg/kg) is given o.s. each day, starting 60 minutes after administration of DNBS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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KeyWords:

Adelmidrol | NF-κB | COX | PPAR | Nuclear factor-κB | Nuclear factor-kappaB | Cyclooxygenase | Peroxisome proliferator-activated receptors | Inhibitor | inhibitor | inhibit

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Adelmidrol
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HY-B1026
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