2. NF-κB
  3. Keap1-Nrf2
  4. biKEAP1

biKEAP1 (compound 3) is an inhibitor targeting the dimerKEAP1. biKEAP1 binds to cellular KEAP1 dimers and releases the NRF2 protein sequestered by KEAP1, resulting in immediate activation of NRF2. biKEAP1 also promotes nuclear translocation of NRF2 and directly inhibits proinflammatory cytokine transcription. biKEAP1 can reduce acute inflammation and reduce inflammatory damage in acute inflammation models.

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biKEAP1 Chemical Structure

biKEAP1 Chemical Structure

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biKEAP1 Related Antibodies

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Description

biKEAP1 (compound 3) is an inhibitor targeting the dimerKEAP1. biKEAP1 binds to cellular KEAP1 dimers and releases the NRF2 protein sequestered by KEAP1, resulting in immediate activation of NRF2. biKEAP1 also promotes nuclear translocation of NRF2 and directly inhibits proinflammatory cytokine transcription. biKEAP1 can reduce acute inflammation and reduce inflammatory damage in acute inflammation models[1].

Molecular Weight

1321.43

Formula

C61H60N8O18S4
SMILES

O=C(NC1=CC=C(S(=O)(NC2=C3C=CC=CC3=C(N(CC(O)=O)S(=O)(C4=CC=C(OC)C=C4)=O)C=C2)=O)C=C1)CCC(NCCCNC(CCC(NC5=CC=C(S(=O)(NC6=C7C=CC=CC7=C(N(CC(O)=O)S(=O)(C8=CC=C(OC)C=C8)=O)C=C6)=O)C=C5)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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biKEAP1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

biKEAP1biKEAP 1biKEAP-1Keap1-Nrf2BTB E3 ligaseKEAP1NRF2 activationacute inflammationbivalent inhibitorInhibitorinhibitorinhibit

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