1. Immunology/Inflammation
    Anti-infection
  2. Complement System
    SARS-CoV
  3. AMY-101 TFA

AMY-101 TFA (Synonyms: Cp40 TFA)

Cat. No.: HY-P1717A Purity: 99.94%
Handling Instructions

AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

AMY-101 TFA Chemical Structure

AMY-101 TFA Chemical Structure

CAS No. : 1789738-04-0

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1 mg USD 400 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation[1][2].

IC50 & Target

KD: 0.5 nM (C3)[1].

In Vivo

AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis[1].
AMY-101 can induce a long-lasting anti-inflammatory effect[1].
AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old; 5.0-7.6 kg body weight)[1].
Dosage: 0.1 mg/site; 50 μL of 2 mg/mL solution.
Administration: Injected locally. (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment.)
Result: Does not cause irritation in healthy gingiva.
Clinical Trial
Formula

C₈₃H₁₁₇N₂₃O₁₈S₂.xC₂HF₃O₂

CAS No.

1789738-04-0

Sequence

Tyr-Ile-Cys-Val-{Trp(Me)}-Gln-Asp-Trp-{Sar}-Ala-His-Arg-Cys-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13)

Sequence Shortening

YICV-{Trp(Me)}-QDW-{Sar}-AHRC-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Protect from light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic)

H2O : 100 mg/mL (Need ultrasonic)

References

Purity: 99.94%

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Keywords:

AMY-101Cp40AMY101AMY 101Cp 40Cp-40Complement SystemSARS-CoVSARS coronavirusperiodontitisinflammatoryInhibitorinhibitorinhibit

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AMY-101 TFA
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HY-P1717A
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