1. GPCR/G Protein
  2. LPL Receptor
  3. SEW​2871

SEW​2871 

Cat. No.: HY-W008947
Handling Instructions

SEW2871 is a highly selective, orally active S1P1 agonist with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood and has therapeutic implications in contexts of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.

For research use only. We do not sell to patients.

SEW​2871 Chemical Structure

SEW​2871 Chemical Structure

CAS No. : 256414-75-2

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Description

SEW2871 is a highly selective, orally active S1P1 agonist with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood and has therapeutic implications in contexts of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses[1][2].

IC50 & Target

EC50: 13.8 nM (S1P1)[2]

Molecular Weight

440.36

Formula

C₂₀H₁₀F₆N₂OS

CAS No.

256414-75-2

SMILES

FC(C1=CC(C2=NOC(C3=CC(C4=CC=CC=C4)=C(C(F)(F)F)S3)=N2)=CC=C1)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SEW​2871LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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