2. Apoptosis Immunology/Inflammation
  3. NO Synthase Caspase Apoptosis
  4. Anticancer agent 157

Anticancer agent 157 (compound 15) is a NO inhibitor (IC50=0.62 μg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase) and caspase 8, causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells (IC50=2.45 μg/mL), Hep-G2 liver cancer cells (IC50=3.25 μg/mL), and B16-F10 murine melanoma cells (IC50=3.84 μg/mL).

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Anticancer agent 157 Chemical Structure

Anticancer agent 157 Chemical Structure

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Description

Anticancer agent 157 (compound 15) is a NO inhibitor (IC50=0.62 μg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase) and caspase 8, causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells (IC50=2.45 μg/mL), Hep-G2 liver cancer cells (IC50=3.25 μg/mL), and B16-F10 murine melanoma cells (IC50=3.84 μg/mL)[1].

IC50 & Target

iNOS (inducible nitric-oxide synthase); caspase 8[1]
Molecular Weight

220.31

Formula

C14H20O2
SMILES

OC1=C(CO)C(C)=C2CCCC(C)(C)C2=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 157 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 157Anticancer agent157Anticancer agent-157NO SynthaseCaspaseApoptosisNitric oxide synthasesNOSanti-inflammatoryanticancercassane diterpenoidsdockingfunction-oriented synthesisInhibitorinhibitorinhibit

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