Tiaprofenic acid

Cat. No.: HY-106579 Purity: 99.33%: FAQs
Data Sheet SDS COA Handling Instructions

Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases.

For research use only. We do not sell to patients.

Tiaprofenic acid Chemical Structure

CAS No. : 33005-95-7

Size	Price	Stock	Quantity
Solution
10 mM * 1 mL in DMSO	USD 72	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 72	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Tiaprofenic acid:

Tiaprofenic acid-d₃ In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

Female Lewis rats received either Tiaprofenic acid (as an intravenous (iv.) bolus injection of 15 mg/kg and constant infusion of 0.02 mg/min) for 6 h. Tiaprofenic acid results in a significant decrease in serum sulfate concentrations and increase in sulfate clearance ratio. There is also a significant decrease in the fraction of sulfate reabsorbed by the kidneys^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

260.31

Appearance

Solid

Formula

C₁₄H₁₂O₃S

CAS No.

33005-95-7

SMILES

O=C(C1=CC=CC=C1)C2=CC=C(C(C)C(O)=O)S2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (384.16 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8416 mL	19.2079 mL	38.4157 mL
5 mM	0.7683 mL	3.8416 mL	7.6831 mL
10 mM	0.3842 mL	1.9208 mL	3.8416 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.33%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (246 KB) HNMR (257 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. G L Plosker, et al. Tiaprofenic Acid. A Reappraisal of Its Pharmacological Properties and Use in the Management of Rheumatic Diseases. Drugs. 1995 Dec;50(6):1050-75. [Content Brief]

[2]. L J Benincosa, et al. Tiaprofenic Acid Inhibits the Renal Reabsorption of Sulfate in Rats. Prostaglandins Leukot Essent Fatty Acids. 1993 Jul;49(1):503-8. [Content Brief]