1. Immunology/Inflammation
  2. COX
  3. Tiaprofenic acid

Tiaprofenic acid 

Cat. No.: HY-106579 Purity: 99.33%
Handling Instructions

Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases.

For research use only. We do not sell to patients.

Tiaprofenic acid Chemical Structure

Tiaprofenic acid Chemical Structure

CAS No. : 33005-95-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 72 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 65 In-stock
Estimated Time of Arrival: December 31
10 mg USD 95 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases[1].

In Vivo

Female Lewis rats received either Tiaprofenic acid (as an intravenous (iv.) bolus injection of 15 mg/kg and constant infusion of 0.02 mg/min) for 6 h. Tiaprofenic acid results in a significant decrease in serum sulfate concentrations and increase in sulfate clearance ratio. There is also a significant decrease in the fraction of sulfate reabsorbed by the kidneys[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

260.31

Formula

C₁₄H₁₂O₃S

CAS No.
SMILES

O=C(C1=CC=CC=C1)C2=CC=C(C(C)C(O)=O)S2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (384.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8416 mL 19.2079 mL 38.4157 mL
5 mM 0.7683 mL 3.8416 mL 7.6831 mL
10 mM 0.3842 mL 1.9208 mL 3.8416 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.60 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.33%

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Keywords:

Tiaprofenic acidCOXCyclooxygenasenonsteroidalanti-inflammatorydruganalgesicrheumatoidarthritisosteoarthritisInhibitorinhibitorinhibit

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Product Name:
Tiaprofenic acid
Cat. No.:
HY-106579
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