1. Immunology/Inflammation
  2. COX
  3. Zaltoprofen

Zaltoprofen (Synonyms: CN100)

Cat. No.: HY-B0619 Purity: 99.09%
Handling Instructions

Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis.

For research use only. We do not sell to patients.

Zaltoprofen Chemical Structure

Zaltoprofen Chemical Structure

CAS No. : 74711-43-6

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10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 65 In-stock
Estimated Time of Arrival: December 31
50 mg USD 135 In-stock
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100 mg USD 185 In-stock
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Description

Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis. Target: COX Zaltoprofen, a preferential COX-2 inhibitor, exhibited a potent inhibitory action on the nociceptive responses induced by a retrograde infusion of bradykinin into the right common carotid artery in rats. Zaltoprofen had a moderate inhibitory effect compared with those of the above-mentioned NSAIDs. the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses is not explainable by the inhibition of cyclooxygenase (COX). Zaltoprofen did not bind to B(1) and B(2) receptors in a radio-ligand binding assay. In the cultured dorsal root ganglion cells of mature mice, zaltoprofen completely inhibited the bradykinin-induced increase of [Ca(2+)](i), which was inhibited by B(2) antagonist D-Arg-[Hyp(3), Thi(5,8), D-Phe(7)]-bradykinin, but not by B(1) antagonist. [1].

IC50 & Target[1]

COX-2

111 μM (IC50)

COX-1

149 μM (IC50)

Clinical Trial
Molecular Weight

298.36

Formula

C₁₇H₁₄O₃S

CAS No.

74711-43-6

SMILES

CC(C1=CC=C(SC2=C3C=CC=C2)C(CC3=O)=C1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (335.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3517 mL 16.7583 mL 33.5166 mL
5 mM 0.6703 mL 3.3517 mL 6.7033 mL
10 mM 0.3352 mL 1.6758 mL 3.3517 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.09%

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Keywords:

ZaltoprofenCN100CN 100CN-100COXCyclooxygenaseInhibitorinhibitorinhibit

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Zaltoprofen
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