4'',5''-Dehydroisopsoralidin
4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC50: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners.
For research use only. We do not sell to patients.
- CAS No.: 65639-51-2
- Formula: C20H14O5
- Molecular Weight:334.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
β-glucuronidase[1]
4'',5''-Dehydroisopsoralidin (compound 5, 15 min) inhibits the release of β-glucuronidase in polymorphonuclear leukocytes (PMNs) of rats, with an IC50 value of 6.3 μM[1].
4'',5''-Dehydroisopsoralidin (compound 9, 24 h) shows weak cytotoxicity (IC50: >50 μM) to H4IIE, HCT116, C6 cells[2].
4'',5''-Dehydroisopsoralidin (25 μM, 1h) causes significant radical scavenging in H4IIE rat hepatoma cells (TEAC assay)[2].
4'',5''-Dehydroisopsoralidin (compound 5, 15 μM, 60 h) increases lifespan in P. corylifolia (MEP assay)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 65639-51-2
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Molecular Weight 334.32
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Formula C20H14O5
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SMILES
O=C1OC2=CC3=C(C=C2C4=C1C5=C(C=C(C=C5)O)O4)C=CC(C)(C)O3
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. De-Wu Zhang, et al. Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum. J Nat Med. 2012 Apr;66(2):362-6. [Content Brief]
[2]. Christian Limper, et al. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol. 2013 Sep;65(9):1393-408. [Content Brief]
[3]. Tong-Hong Wang, et al. The flavonoid corylin exhibits lifespan extension properties in mouse. Nat Commun. 2022 Mar 9;13(1):1238. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4'',5''-Dehydroisopsoralidin Related Classifications
HY-N9975 Related Classifications
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