4'',5''-Dehydroisopsoralidin 

4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners^[1][2].

β-glucuronidase^[1]

4'',5''-Dehydroisopsoralidin (compound 5, 15 min) inhibits the release of β-glucuronidase in polymorphonuclear leukocytes (PMNs) of rats, with an IC₅₀ value of 6.3 μM^[1].
4'',5''-Dehydroisopsoralidin (compound 9, 24 h) shows weak cytotoxicity (IC₅₀: >50 μM) to H4IIE, HCT116, C6 cells^[2].
4'',5''-Dehydroisopsoralidin (25 μM, 1h) causes significant radical scavenging in H4IIE rat hepatoma cells (TEAC assay)^[2].
4'',5''-Dehydroisopsoralidin (compound 5, 15 μM, 60 h) increases lifespan in P. corylifolia (MEP assay)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

334.32

C₂₀H₁₄O₅

65639-51-2

O=C1OC2=CC3=C(C=C2C4=C1C5=C(C=C(C=C5)O)O4)C=CC(C)(C)O3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. De-Wu Zhang, et al. Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum. J Nat Med. 2012 Apr;66(2):362-6.  [Content Brief]

  [2]. Christian Limper, et al. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol. 2013 Sep;65(9):1393-408.  [Content Brief]

  [3]. Tong-Hong Wang, et al. The flavonoid corylin exhibits lifespan extension properties in mouse. Nat Commun. 2022 Mar 9;13(1):1238.  [Content Brief]