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Troxipide 

Cat. No.: HY-B0758 Purity: 99.39%
Handling Instructions

Troxipide is an orally active defensive factor-enhancing therapeutic agent for gastritis and gastric ulcer (GU). Troxipide is a non-antisecretory gastro protective agent with antiulcer, anti-inflammatory and mucus-secreting properties.

For research use only. We do not sell to patients.

Troxipide Chemical Structure

Troxipide Chemical Structure

CAS No. : 30751-05-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 108 In-stock
Estimated Time of Arrival: December 31
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Description

Troxipide is an orally active defensive factor-enhancing therapeutic agent for gastritis and gastric ulcer (GU). Troxipide is a non-antisecretory gastro protective agent with antiulcer, anti-inflammatory and mucus-secreting properties[1][2].

In Vitro

Troxipide exerts inhibitory, therapeutic and preventive effects to specifically those in the stomach by enhancing gastric mucosal blood flow and gastric mucosal defense factors and promoting tissue repair, blood circulation, metabolism and GU repair[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Troxipide (40 mg/kg; iv) significantly alleviates gastric ulcer (GU)[1].
Troxipide (40 mg/kg; iv) has a T1/2 of 210 min and 428.73 min for NCG and GUG rat, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Normal control group (NCG) and gastric ulcer group (GUG) rat (5% acetic acid 10 mL/kg/day)[1]
Dosage: 10, 20, 40, 60 mg/kg
Administration: Oral; daily; 2 weeks
Result: The levels of these cytokines (IL-17, IL-6, TNF-α, IFN-γ and AP-1) were significantly reduced, suggesting that GU was significantly alleviated.
Animal Model: NCG and GUG rat[1]
Dosage: 40 mg/kg for iv
Administration: IV
Result: Had a T1/2 of 210 min and 428.73 min for NCG and GUG rat, respectively.
Molecular Weight

294.35

Formula

C15H22N2O4

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.09 mg/mL (30.88 mM; Need ultrasonic)

H2O : 1 mg/mL (3.40 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3973 mL 16.9866 mL 33.9732 mL
5 mM 0.6795 mL 3.3973 mL 6.7946 mL
10 mM 0.3397 mL 1.6987 mL 3.3973 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.91 mg/mL (3.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.91 mg/mL (3.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.91 mg/mL (3.09 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Troxipide
Cat. No.:
HY-B0758
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