Olendalizumab
Based on 1 Customer Validation
Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (Ki=60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be used for research of complement mediated disorder caused by corona virus.
For research use only. We do not sell to patients.
- Purity: 97.43%
- CAS No.: 2210314-30-8
- Molecular Weight:146 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG2-G4-kappa
Human
Complement C5/C5a
Olendalizumab can be used as an biotinylated capture reagent, with working concentration of 100 μg/mL in Bioaffy wash 1, while the AlexaFluor labeled anti-C5a clone 2942 is 4 μg/mL in Rexxip F[1].
The members of the complement system such as C3, C5a, C5b-9, including receptors such as C3aR and C5aR mediate the lung injury following viral infection. Moreover, C5/C5a is only non-silent complement in corona virus-induced lung injury. Olendalizumab is the potent C5a inhibitor[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG2-G4-kappa
ELISA, FACS, Functional assay
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Immobilized Complement C5/C5a Protein, Human (HY-P7864) can bind Olendalizumab. The EC50 for this effect is 28.58 ng/mL.
Chemical Information
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CAS No. 2210314-30-8
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Appearance Liquid
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Molecular Weight 146 kDa
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Color Colorless to light yellow
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SMILES
[Olendalizumab]
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Synonyms
ALXN1007; Lendalizumab
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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