1. Immunology/Inflammation
  2. Complement System
  3. Olendalizumab

Olendalizumab  (Synonyms: ALXN1007)

Cat. No.: HY-P99767

Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (Ki=60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be used for research of complement mediated disorder caused by corona virus.

For research use only. We do not sell to patients.

Olendalizumab Chemical Structure

Olendalizumab Chemical Structure

CAS No. : 2210314-30-8

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Description

Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (Ki=60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be used for research of complement mediated disorder caused by corona virus[1][2].

IC50 & Target

Complement protein C5a[1]

In Vitro

Olendalizumab can be used as an biotinylated capture reagent, with working concentration of 100 μg/mL in Bioaffy wash 1, while the AlexaFluor labeled anti-C5a clone 2942 is 4 μg/mL in Rexxip F[1].
The members of the complement system such as C3, C5a, C5b-9, including receptors such as C3aR and C5aR mediate the lung injury following viral infection. Moreover, C5/C5a is only non-silent complement in corona virus-induced lung injury. Olendalizumab is the potent C5a inhibitor[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.
SMILES

[Olendalizumab]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Olendalizumab Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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