1. PI3K/Akt/mTOR Apoptosis Autophagy
  2. PTEN Apoptosis Autophagy
  3. VO-OHPic

VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy.

For research use only. We do not sell to patients.

VO-OHPic Chemical Structure

VO-OHPic Chemical Structure

CAS No. : 675848-25-6

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Top Publications Citing Use of Products

    VO-OHPic purchased from MedChemExpress. Usage Cited in: Redox Biol. 2019 Jan;20:390-401.  [Abstract]

    Immunoblotting analysis show that RES treatment markedly inhibited Ang II-induced degradation of PTEN, activation of AKT and mTOR and inactivation of AMPK, but this effect is reversed by VO-OHpic.

    VO-OHPic purchased from MedChemExpress. Usage Cited in: Redox Biol. 2019 Jan;20:390-401.  [Abstract]

    Western analysis of related genes expression in mice with the treatment of TAC, TAC+RES, and TAC+RES+VO-Ophic.

    VO-OHPic purchased from MedChemExpress. Usage Cited in: Redox Biol. 2019 Jan;20:390-401.  [Abstract]

    Immunoblotting analysis show that RES treatment markedly inhibited Ang II-induced degradation of PTEN, activation of AKT and mTOR and inactivation of AMPK, but this effect is reversed by VO-OHpic.

    VO-OHPic purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2019 Jul 29;10(1):217.  [Abstract]

    Western blot showing the levels of phosphorylated and non-phosphorylated PTEN, AKT, and mTOR proteins before and after VO-OHpic trihydrate treatment.

    VO-OHPic purchased from MedChemExpress. Usage Cited in: Mol Vis. 2018 Jul 23;24:485-494.  [Abstract]

    The miR-21 inhibitor promotes the expression of the PTEN protein and inhibits the expression of p-AKT, and VO-Ohpic trihydrate reverses the effect.
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    Description

    VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy[1][2][3].

    IC50 & Target

    IC50: 46 nM (PTEN)[1]

    Molecular Weight

    361.16

    Formula

    C12H10N2O8V

    CAS No.
    SMILES

    [OH2][V+2]([N]1=CC=CC(O)=C1C2=O)([O-]2)([O-]C3=CC=CN=C3C4=O)([O-]4)=O.[H+]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
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    VO-OHPic Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    VO-OHPic
    Cat. No.:
    HY-110067
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