1. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
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  3. Gedunin

Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research.

For research use only. We do not sell to patients.

Gedunin Chemical Structure

Gedunin Chemical Structure

CAS No. : 2753-30-2

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Based on 1 publication(s) in Google Scholar

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Description

Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research[3].

IC50 & Target[2]

HSP90

 

In Vitro

Gedunin (0.5-30 μM) inhibits CaCo-2 colon cancer cell proliferationin a dose-dependent manner, and the IC50 value is 16.83 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

482.57

Formula

C28H34O7

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@](O2)([H])[C@@]32[C@](CC[C@]4([H])[C@@]5(C)C=CC(C(C)(C)[C@]5([H])C[C@@H](OC(C)=O)[C@]43C)=O)(C)[C@H](C6=COC=C6)O1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

References
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Gedunin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Gedunin
Cat. No.:
HY-107577
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