PTHR

Parathyroid hormone receptor

PTHR is a G protein-coupled receptor (GPCR) that regulates calcium and phosphate homeostasis, bone formation, and renal function. PTHR is activated by PTH, PTH-related peptide (PTHrP), and tuberoinfundibular peptide of 39 residues (TIP39), which activates G-protein and initiates downstream signaling cascades such as Gαs/cAMP/PKA signaling pathway. PTHR promotes the release of calcium ions from bones and increases the kidneys' reabsorption of calcium ions, thereby maintaining blood calcium homeostasis. PTHR also reduces blood phosphorus levels by promoting renal phosphorus excretion. PTHR participates in bone formation, cartilage development, and the development of the pancreas, teeth and mammary glands. PTHR exists in three isoforms, PTH1R, PTH2R and PTH3R. PTH1R has a high affinity for PTH and PTHrP and is the main receptor for calcium homeostasis regulation. PTH2R has a high affinity for TIP39 and is involved in the functional regulation of the central nervous system. PTH3R is mainly expressed in non-mammalian vertebrates and has a higher affinity for PTHrP. PTHR dysfunction could lead to Blomstrand’s lethal chondroplasia, Ollier’s disease, Jansen’s metaphyseal chondroplasia, hypoparathyroidism, hyperparathyroidism and osteoporosis^[1]^[2].

References:

[1]. Cheloha RW, et al., PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Nat Rev Endocrinol. 2015 Dec;11(12):712-24. [Content Brief]

[2]. On JS, et al., Evolution of parathyroid hormone receptor family and their ligands in vertebrate. Front Endocrinol (Lausanne). 2015 Mar 10;6:28. [Content Brief]

PTHR Isoform Specific Products:

PTHR Isoform Comparison

PTHR Related Products (33)
Antibodies (1)
PTHR Isoform Comparison

By Effects:	Inhibitor (1) Agonists (11) Ligand (1) Antagonists (5) Activators (5)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P0059

Teriparatide	Agonist	99.98%
Teriparatide (Human parathyroid hormone-(1-34)) is a PTH1 receptor agonist. Teriparatide (Human parathyroid hormone-(1-34)) can be used for osteoporosis research.

HY-100856

PCO371	Agonist	99.67%
PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.

HY-108742

Abaloparatide	Activator	99.82%
Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis.

HY-P4385

(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat)	Antagonist	99.32%
(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent PTH-1R antagonist and does not display any partial agonist activity.

HY-106288

Human PTHrP-(1-36)		99.95%
Human PTHrP-(1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP-(1-36) enhances beta cell function and proliferation. Human PTHrP-(1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism.

HY-P992296

Anti-PTHrP Antibody
Anti-PTHrP Antibody is a monoclonal antibody that targets PTHrP. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PTHrP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-176945

PTH1R agonist 3	Agonist
PTH1R agonist 3 (Example 47) is a parathyroid hormone 1 receptor (PTH1R) agonist with a pEC₅₀ value of less than 6. PTH1R agonist 3 can be used for the study of bone diseases, such as osteoporosis.

HY-176944

PTH1R agonist 2	Agonist
PTH1R agonist 2 (example 3) is a parathyroid hormone 1 receptor (PTH1R) agonist. PTH1R agonist 2 can be used for research of hypoparathyroidism and osteoporosis.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Agonist	99.84%
TIP 39, Tuberoinfundibular Neuropeptide is an endogenous PTH2 receptor agonist and antihypertensive agent. TIP 39, Tuberoinfundibular Neuropeptide selectively activates the PTH2 receptor with no activity on the PTH1 receptor, stimulates cAMP production, activates adenylate cyclase, and elevates intracellular calcium levels via mobilization from intracellular stores. TIP 39, Tuberoinfundibular Neuropeptide is highly conserved in humans, mice, and rats. TIP 39, Tuberoinfundibular Neuropeptide is applicable to research related to nociception and inflammation-induced pain.

HY-148350

DS69910557	Antagonist	98.86%
DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC₅₀ value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.

HY-108742A

Abaloparatide TFA	Activator	99.51%
Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis.

HY-125879

DS08210767	Antagonist	99.40%
DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC₅₀ of 90 nM.

HY-15103

AH3960	Agonist	99.92%
AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC₅₀ value of 0.82 μM. AH3960 also serves as an agonist of parathyroid hormone receptor-1 (PTHR1).

HY-P4715

(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)		99.08%
(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat) is a peptide and can be used as a parathyroid hormone (PTH) receptor ligand.

HY-P4849

pTH-Related Protein (1-37) (human, mouse, rat)	Activator
pTH-Related Protein (1-37) (human, mouse, rat), the peptide analogue of pTH-Related Protein (pTHrP). pTHrP refers to parathyroid-hormone-related protein, involved in physiological regulation of bone formation.

HY-P10309

[Nle8,18,Tyr34]-pTH (3-34) amide (human)	Ligand
[Nle8,18,Tyr34]-pTH (3-34) amide human ([Nle8,18,Tyr34]hPTH (3-34) amide) is a parathyroid hormone (PTH) analog.

HY-113918

SW-106	Antagonist
SW-106 is a parathyroid hormone receptor 1 (PTHR1) antagonist. SW106 antagonizes PTHR1-mediated cAMP signaling induced by the peptide analog, M-PTH (1-11), as well as by the native PTH (1-9) sequence, as tethered to the extracellular end of transmembrane domain (TMD) helix-1 of the receptor. SW-106 can be used for the research of metabolic disease.

HY-P0059A

Teriparatide acetate hydrate	Agonist
Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) is a PTH1 receptor agonist. Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) can be used for osteoporosis research.

HY-P4856

pTH-Related Protein (1-40) (human, mouse, rat)	Activator
pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1).

HY-176943

PTH1R agonist 1	Agonist
PTH1R agonist 1 (Example 2) is a parathyroid hormone 1 receptor (PTH1R) agonist. PTH1R agonist 1 can be used for research of hypoparathyroidism and osteoporosis.

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PTHR

PTHR Isoform Specific Products:

PTHR Isoform Specific Products:

PTHR Related Products (33)

Antibodies (1)

PTHR Isoform Comparison

PTHR Related Products (33):