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  2. Thyroid Hormone Receptor

PCO371 

Cat. No.: HY-100856
Handling Instructions

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.

For research use only. We do not sell to patients.

PCO371 Chemical Structure

PCO371 Chemical Structure

CAS No. : 1613373-33-3

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5 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.

IC50 & Target

PTHR1[1]

In Vitro

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. PCO371 induces cAMP production with an EC50 of 2.4 μM in COS-7 cells expressing hPTHR1, and 2.5 μM in COS-7 cells transfected with hPTHR1-delNT, and also enhances the phospholipase C activity (EC50, 17 μM)[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.5732 mL 7.8660 mL 15.7319 mL
5 mM 0.3146 mL 1.5732 mL 3.1464 mL
10 mM 0.1573 mL 0.7866 mL 1.5732 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

635.65

Formula

C₂₉H₃₂F₃N₅O₆S

CAS No.

1613373-33-3

SMILES

FC(F)(F)OC1=CC=C(C2=NC3(CCN(S(CCC4=C(C)C=C(N5C(NC(C5(C)C)=O)=O)C=C4C)(=O)=O)CC3)C(N2)=O)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
PCO371
Cat. No.:
HY-100856
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