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  3. PCO371

PCO371 

Cat. No.: HY-100856
Handling Instructions

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.

For research use only. We do not sell to patients.

PCO371 Chemical Structure

PCO371 Chemical Structure

CAS No. : 1613373-33-3

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Description

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.

IC50 & Target

PTHR1[1]

In Vitro

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. PCO371 induces cAMP production with an EC50 of 2.4 μM in COS-7 cells expressing hPTHR1, and 2.5 μM in COS-7 cells transfected with hPTHR1-delNT, and also enhances the phospholipase C activity (EC50, 17 μM)[1].

Clinical Trial
Molecular Weight

635.65

Formula

C₂₉H₃₂F₃N₅O₆S

CAS No.

1613373-33-3

SMILES

FC(F)(F)OC1=CC=C(C2=NC3(CCN(S(CCC4=C(C)C=C(N5C(NC(C5(C)C)=O)=O)C=C4C)(=O)=O)CC3)C(N2)=O)C=C1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PCO371
Cat. No.:
HY-100856
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