Human PTHrP-(1-36)
Based on 1 Customer Validation
Human PTHrP-(1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP-(1-36) enhances beta cell function and proliferation. Human PTHrP-(1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 172867-62-8
- Formula: C191H305N59O52
- Molecular Weight:4259.83
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human PTHrP-(1-36) (EC50: 0.05 nM) increases intracellular calcium in human epidermal keratinocytes[2].
Human PTHrP-(1-36) (100 nM, 24 h) increases human β-cell proliferation[3].
Human PTHrP-(1-36) (100 nM, 30 min) enhances insulin secretion in human islets[3].
PTHrP-(1-36) (mouse, EC50: 1 nM) induces a rapid Ca2+ response in UMR 106 cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PTHrP-(1-36) (mouse, 100 μg/kg, s.c., every other day) reverses the observed decrease of Wisp1 expression in the diabetic mice[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 172867-62-8
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Appearance Solid
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Molecular Weight 4259.83
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Formula C191H305N59O52
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Color White to off-white
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Sequence Shortening
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEI
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
H2O : 100 mg/mL (23.48 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: Saline
Solubility: ≥ 25 mg/mL (5.87 mM); Clear solution
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Everhart-Caye M, et al. Parathyroid hormone (PTH)-related protein(1-36) is equipotent to PTH(1-34) in humans. J Clin Endocrinol Metab. 1996 Jan;81(1):199-208. [Content Brief]
[2]. Orloff JJ, et al. Analysis of PTHRP binding and signal transduction mechanisms in benign and malignant squamous cells. Am J Physiol. 1992 May;262(5 Pt 1):E599-607. [Content Brief]
[3]. Guthalu Kondegowda N, et al. Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes. 2010 Dec;59(12):3131-8. [Content Brief]
[4]. Valín A, et al. C-terminal parathyroid hormone-related protein (PTHrP) (107-139) stimulates intracellular Ca(2+) through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells. Endocrinology. 2001 Jul;142(7):2752-9. [Content Brief]
[6]. Portal-Núñez S, et al. Alterations of the Wnt/beta-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice. FEBS Lett. 2010 Jul 16;584(14):3095-100. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.2348 mL | 1.1738 mL | 2.3475 mL | 5.8688 mL |
| 5 mM | 0.0470 mL | 0.2348 mL | 0.4695 mL | 1.1738 mL | |
| 10 mM | 0.0235 mL | 0.1174 mL | 0.2348 mL | 0.5869 mL | |
| 15 mM | 0.0157 mL | 0.0783 mL | 0.1565 mL | 0.3913 mL | |
| 20 mM | 0.0117 mL | 0.0587 mL | 0.1174 mL | 0.2934 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Human PTHrP-(1-36) Related Classifications
HY-106288 Related Classifications
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