2. Signaling Pathways
  3. GPCR/G Protein
  4. PTHR
  5. PTHR Antagonist

PTHR Antagonist

PTHR Isoform Comparison

PTHR Antagonists (6):

Cat. No. Product Name Effect Purity
  • HY-P4385
    (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat)
    		Antagonist 99.32%
    (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent PTH-1R antagonist and does not display any partial agonist activity.
  • HY-148350
    DS69910557
    		Antagonist 98.86%
    DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.
  • HY-125879
    DS08210767
    		Antagonist 99.40%
    DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.
  • HY-113918
    SW-106
    		Antagonist
    SW-106 is a parathyroid hormone receptor 1 (PTHR1) antagonist. SW106 antagonizes PTHR1-mediated cAMP signaling induced by the peptide analog, M-PTH (1-11), as well as by the native PTH (1-9) sequence, as tethered to the extracellular end of transmembrane domain (TMD) helix-1 of the receptor. SW-106 can be used for the research of metabolic disease.
  • HY-186200
    PTHR1 antagonist 1
    		Antagonist
    PTHR1 antagonist 1 (Compound 18) is a PTHR1 antagonist with an IC50 of 0.090 µM. PTHR1 antagonist 1 is applicable to the research of calcium metabolism disorders.
  • HY-131206
    DS37571084
    		Antagonist
    DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC50 value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism.