PTHR Antagonist

(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent PTH-1R antagonist and does not display any partial agonist activity.

PTHR1 antagonist 1 is a PTHR1 antagonist with an IC₅₀ of 0.090 µM. PTHR1 antagonist 1 is applicable to the research of calcium metabolism disorders.

DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC₅₀ value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.

DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC₅₀ of 90 nM.

SW-106 is a selective antagonist of parathyroid hormone/parathyroid hormone-related peptide receptor (PPR) and PTHR1, with an IC₅₀ value of 0.99 μM against PPR. SW-106 antagonizes cAMP responses. SW-106 can be used in the research of osteoporosis.

DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC₅₀ value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism.