2. GPCR/G Protein
  3. PTHR
  4. DS37571084

DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC50 value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism.

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DS37571084

DS37571084 Chemical Structure

CAS No. : 2460353-87-9

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DS37571084 Related Antibodies

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Description

DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC50 value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism[1].

IC50 & Target[1]

PTH1R

0.17 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
CHO-K1 IC50
0.17 μM
Compound: 12; DS37571084
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins
[PMID: 32345459]
Molecular Weight

525.47

Formula

C28H30Cl2N4O2
CAS No.
SMILES

O=C1N(C2=CC=C(NCCNC3CCOCC3)C=C2)C4=CC(Cl)=CC=C4C5=CC(Cl)=CN=C5C1(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DS37571084 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS375710842460353-87-9DS 37571084DS-37571084PTHRParathyroid hormone receptorHyperparathyroidismPTHR1Inhibitorinhibitorinhibit

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HY-131206
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