2460353-87-9
Chemical Structure
DS37571084
- CAS No.: 2460353-87-9
- Formula:C28H30Cl2N4O2
- Molecular Weight:525.47
IUPAC Name: 2,9-dichloro-5,5-dimethyl-7-(4-((2-((tetrahydro-2H-pyran-4-yl)amino)ethyl)amino)phenyl)-5,7-dihydro-6H-benzo[b]pyrido[3,2-d]azepin-6-one
InChIKey: WDUWMDCPYOHPHT-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=C(NCCNC3CCOCC3)C=C2)C4=CC(Cl)=CC=C4C5=CC(Cl)=CN=C5C1(C)C
Biological Activity: DS37571084 is an orally active competitive antagonist of parathyroid hormone receptor 1 (PTH1R) with an IC50 value of 0.17 μM. DS37571084 is applicable to the research of bone diseases and calcium metabolism disorders associated with primary hyperparathyroidism[1][2].
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DS37571084 | DS37571084 is an orally active competitive antagonist of parathyroid hormone receptor 1 (PTH1R) with an IC50 value of 0.17 μM. DS37571084 is applicable to the research of bone diseases and calcium metabolism disorders associated with primary hyperparathyroidism. | |||||||||||||||||||||
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- [1]. Arai Y, et al. Discovery of novel, potent, and orally bioavailable pyrido[2,3-d][1]benzazepin-6-one antagonists for parathyroid hormone receptor 1. Bioorganic & medicinal chemistry. 2020 Jun 01;28(11):115524. [Content Brief]
- [2]. Iwanowska M, et al. Bone Disease in Primary Hyperparathyroidism-Changes Occurring in Bone Metabolism and New Potential Treatment Strategies. International journal of molecular sciences. 2024 Oct 30;25(21):11639.
Keywords
