PTHR
Parathyroid hormone receptor
PTHR is a G protein-coupled receptor (GPCR) that regulates calcium and phosphate homeostasis, bone formation, and renal function. PTHR is activated by PTH, PTH-related peptide (PTHrP), and tuberoinfundibular peptide of 39 residues (TIP39), which activates G-protein and initiates downstream signaling cascades such as Gαs/cAMP/PKA signaling pathway. PTHR promotes the release of calcium ions from bones and increases the kidneys' reabsorption of calcium ions, thereby maintaining blood calcium homeostasis. PTHR also reduces blood phosphorus levels by promoting renal phosphorus excretion. PTHR participates in bone formation, cartilage development, and the development of the pancreas, teeth and mammary glands. PTHR exists in three isoforms, PTH1R, PTH2R and PTH3R. PTH1R has a high affinity for PTH and PTHrP and is the main receptor for calcium homeostasis regulation. PTH2R has a high affinity for TIP39 and is involved in the functional regulation of the central nervous system. PTH3R is mainly expressed in non-mammalian vertebrates and has a higher affinity for PTHrP. PTHR dysfunction could lead to Blomstrand’s lethal chondroplasia, Ollier’s disease, Jansen’s metaphyseal chondroplasia, hypoparathyroidism, hyperparathyroidism and osteoporosis[1][2].
References:
- [1]. Cheloha RW, et al., PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Nat Rev Endocrinol. 2015 Dec;11(12):712-24. [Content Brief]
- [2]. On JS, et al., Evolution of parathyroid hormone receptor family and their ligands in vertebrate. Front Endocrinol (Lausanne). 2015 Mar 10;6:28. [Content Brief]
PTHR Isoform Specific Products
All Product Categories
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PTHR Related Products (38)
Related Products (38)
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Antibodies (1)
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PTHR Isoform Comparison
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Teriparatide acetate hydrate
0 ImagesCat. No.: HY-P0059ACAS No.: 99294-94-7Synonyms: Human parathyroid hormone-(1-34) acetate hydrate; hPTH (1-34) acetate hydrateTeriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) is a PTH1 receptor agonist. Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) can be used for osteoporosis research.
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PTH1R agonist 3
0 ImagesCat. No.: HY-176945CAS No.: 3106619-38-6PTH1R agonist 3 (Example 47) is a parathyroid hormone 1 receptor (PTH1R) agonist with a pEC50 value of less than 6. PTH1R agonist 3 can be used for the study of bone diseases, such as osteoporosis.
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PTH1R agonist 2
0 ImagesCat. No.: HY-176944CAS No.: 3106850-44-3PTH1R agonist 2 (example 3) is a parathyroid hormone 1 receptor (PTH1R) agonist. PTH1R agonist 2 can be used for research of hypoparathyroidism and osteoporosis.
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pTH-Related Protein (1-40) (human, mouse, rat)
0 ImagesCat. No.: HY-P4856CAS No.: 120298-73-9pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1).
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PTH1R agonist 1
0 ImagesCat. No.: HY-176943CAS No.: 3106336-35-7PTH1R agonist 1 (Example 2) is a parathyroid hormone 1 receptor (PTH1R) agonist. PTH1R agonist 1 can be used for research of hypoparathyroidism and osteoporosis.
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Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)
0 ImagesCat. No.: HY-P4798CAS No.: 155918-12-0Synonyms: Human PTHrP(107-111) amideOsteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) is a C-terminal parathyroid hormone-related protein fragment that can inhibit bone resorption.
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Osteostatin
0 ImagesCat. No.: HY-P4684CAS No.: 138949-73-2Synonyms: PTHrP (107–111)Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research.
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DS37571084
0 ImagesCat. No.: HY-131206CAS No.: 2460353-87-9DS37571084 is an orally active competitive antagonist of parathyroid hormone receptor 1 (PTH1R) with an IC50 value of 0.17 μM. DS37571084 is applicable to the research of bone diseases and calcium metabolism disorders associated with primary hyperparathyroidism.
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Tigapotide
0 ImagesCat. No.: HY-16498CAS No.: 848084-83-3Synonyms: PCK-3145Tigapotide (PCK-3145) is a synthetic 15-mer peptide derived from prostate-secretory protein, and acts as an antineoplastic agent. Tigapotide inhibits tumor growth, experimental bone metastasis, and malignancy-associated hypocalcemia. Tigapotide induces apoptosis in prostate cancer cells and tumors, and suppresses the growth of prostate cancer cells. Tigapotide inhibits the production of parathyroid hormone-related protein (PTHrP) in tumors and plasma. Tigapotide reduces plasma calcium levels in hypercalcemic tumor-bearing rats. Tigapotide is applicable for the research of prostate cancer and malignancy-associated hypercalcemia.
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CH5447240
0 ImagesCat. No.: HY-120398CAS No.: 1253919-92-4CH5447240 is an agonist for parathyroid hormone receptor 1 (PTHR1), that inhibits human PTHR1 with an EC50 of 12 μM. CH5447240 exhibits good metabolic stability in human liver microsomes. CH5447240 increases serum calcium levels in rats. CH5447240 can be used in research about hypoparathyroidism.
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pTH (1-84) (dog)
0 ImagesCat. No.: HY-P4827CAS No.: 521986-14-1pTH (1-84) dog is a biologically active full-length canine parathyroid hormone, as well as an agonist of PTHR. pTH (1-84) dog can be detected by the "intact" PTH (W-PTH) assay, thus effectively distinguishing inactive C-terminal fragments. In terms of metabolic regulation, it rapidly and persistently stimulates hepatic glucose release, hepatic alanine uptake, and alanine-based gluconeogenesis in conscious fasted dogs, and causes a secondary increase in circulating canine insulin levels due to enhanced glucose release. However, high doses of pTH (1-84) (dog) may induce adverse reactions such as hypercalcemia in dogs. Based on the above characteristics, this hormone can be widely used in studies related to canine hyperadrenocorticism (HAC).
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3-epi-Calcifediol
0 ImagesCat. No.: HY-32351BCAS No.: 73809-05-9Synonyms: 3-epi-25-Hydroxy cholecalciferol3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
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Octadecyl β-D-glucopyranosiduronic acid
0 ImagesCat. No.: HY-179356CAS No.: 1413439-62-9Octadecyl β-D-glucopyranosiduronic acid (Compound 9) is a parathyroid hormone 1 receptor (PTH1R) activator, with a pEC50 value > 9. Octadecyl β-D-glucopyranosiduronic acid can be used for research on hypoparathyroidism.
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Tigapotide TFA
0 ImagesCat. No.: HY-16497CAS No.: 848084-84-4Synonyms: PCK 3145 TFATigapotide TFA (PCK-3145 TFA) is a synthetic 15-mer peptide derived from prostate-secretory protein, and acts as an antineoplastic agent. Tigapotide TFA inhibits tumor growth, experimental bone metastasis, and malignancy-associated hypocalcemia. Tigapotide TFA induces Apoptosis in prostate cancer cells and tumors, and suppresses the growth of prostate cancer cells. Tigapotide TFA inhibits the production of parathyroid hormone-related protein (PTHrP) in tumors and plasma. Tigapotide TFA reduces plasma calcium levels in hypercalcemic tumor-bearing rats. Tigapotide TFA is applicable for the research of prostate cancer and malignancy-associated hypercalcemia.
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3-epi-Calcifediol (Standard)
0 ImagesCat. No.: HY-32351BRCAS No.: 73809-05-9Synonyms: 3-epi-25-hydroxy Cholecalciferol (Standard)3-epi-Calcifediol (Standard) is the analytical standard of 3-epi-Calcifediol. This product is intended for research and analytical applications. 3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
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PCO371 (Standard)
0 ImagesCat. No.: HY-100856RCAS No.: 1613373-33-3
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Human PTHrP-(1-36) (Standard)
0 ImagesCat. No.: HY-106288RCAS No.: 172867-62-8Human PTHrP-(1-36) (Standard) is the analytical standard of Human PTHrP-(1-36) (HY-106288). This product is intended for research and analytical applications. Human PTHrP-(1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP-(1-36) enhances beta cell function and proliferation. Human PTHrP-(1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism.
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PTH1R agonist 4
0 ImagesCat. No.: HY-176946CAS No.: 3106619-54-6PTH1R agonist 4 (Example 63) is a parathyroid hormone 1 receptor (PTH1R) agonist with a pEC50 value greater than 7. PTH1R agonist 4 can be used for the study of bone diseases, such as osteoporosis.
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