pTH (1-84) (dog)
pTH (1-84) dog is a biologically active full-length canine parathyroid hormone, as well as an agonist of PTHR. pTH (1-84) dog can be detected by the "intact" PTH (W-PTH) assay, thus effectively distinguishing inactive C-terminal fragments. In terms of metabolic regulation, it rapidly and persistently stimulates hepatic glucose release, hepatic alanine uptake, and alanine-based gluconeogenesis in conscious fasted dogs, and causes a secondary increase in circulating canine insulin levels due to enhanced glucose release. However, high doses of pTH (1-84) (dog) may induce adverse reactions such as hypercalcemia in dogs. Based on the above characteristics, this hormone can be widely used in studies related to canine hyperadrenocorticism (HAC).
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- CAS No.: 521986-14-1
- Formule: C414H672N122O128S2
- Masse moléculaire:9470.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
pTH (1-84) dog (1/1:1/256) reliably measured by the W-PTH assay in isolated dog plasma samples with accurate detection down to ~5 pg/mL, produces parallel dilution curves with isolated human plasma, and shows high correlation with I-PTH measurements in isolated dog plasma[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
pTH (1-84) dog (measured as W-PTH) is metabolized more rapidly than I-PTH in the first 2.5 minutes after parathyroidectomy, with levels falling to 25% of pre-surgical values[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 521986-14-1
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Masse moléculaire 9470.64
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Formule C414H672N122O128S2
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Sequence
Ser-Val-Ser-Glu-Ile-Gln-Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-Val-Ala-Leu-Gly-Ala-Pro-Ile-Ala-His-Arg-Asp-Gly-Ser-Ser-Gln-Arg-Pro-Leu-Lys-Lys-Glu-Asp-Asn-Val-Leu-Val-Glu-Ser-Tyr-Gln-Lys-Ser-Leu-Gly-Glu-Ala-Asp-Lys-Ala-Asp-Val-Asp-Val-Leu-Thr-Lys-Ala-Lys-Ser-Gln
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Sequence Shortening
SVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNFVALGAPIAHRDGSSQRPLKKEDNVLVESYQKSLGEADKADVDVLTKAKSQ
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[2]. Estepa J C, et al. Dynamics of secretion and metabolism of PTH during hypo‐and hypercalcaemia in the dog as determined by the ‘intact’and ‘whole’PTH assays[J]. Nephrology Dialysis Transplantation, 2003, 18(6): 1101-1107. [Content Brief]
[3]. Hruska K A, et al. Effect of intact parathyroid hormone on hepatic glucose release in the dog[J]. The Journal of Clinical Investigation, 1979, 64(4): 1016-1023. [Content Brief]
[4]. Nishitani K, et al. High dose teriparatide (rPTH1-34) therapy increases callus volume and enhances radiographic healing at 8-weeks in a massive canine femoral allograft model[J]. PLoS One, 2017, 12(10): e0185446. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
pTH (1-84) (dog) Related Classifications
HY-P4827 Related Classifications
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