155918-12-0
155918-12-0
Chemical Structure
Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)
Synonym(s): Human PTHrP(107-111) amide
- CAS No.: 155918-12-0
- Formula:C27H42N10O7
- Molecular Weight:618.69
InChIKey: LNQSOPRLNRSQRD-TWGJCYIBSA-N
SMILES: C[C@@H](O)[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@H](C(N)=O)CC1=CNC2=CC=CC=C12)=O)=O)=O)=O
Biological Activity: Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) is a C-terminal parathyroid hormone-related protein fragment that can inhibit bone resorption[1][2].
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Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) | Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) is a C-terminal parathyroid hormone-related protein fragment that can inhibit bone resorption. | |||||||||||||||||||||
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References
- [1]. Murrills RJ, et al. Lack of significant effect of carboxyl-terminal parathyroid hormone-related peptide fragments on isolated rat and chick osteoclasts. Calcif Tissue Int. 1995 Jul;57(1):47-51. [Content Brief]
- [2]. Whitfield JF, et al. C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), and the N-terminal PTHrP-(1-40) fragment stimulate membrane-associated protein kinase C activity in rat spleen lymphocytes. J Cell Physiol. 1994 Mar;158(3):518-22. [Content Brief]
